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    Ubc6 Ubiquitin conjugating enzyme 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40610, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ubc6provided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0004436
    Locus tag
    Dmel_CG2013
    See related
    AllianceGenome:FB:FBgn0004436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE56673; CG2013; Dhr6; Dmel\CG2013; dRad6; dRAD6; Rad6; RAD6; Rad6a; UBC6; Ubcd6; UbcD6
    Summary
    Enables p53 binding activity; protein domain specific binding activity; and ubiquitin conjugating enzyme activity. Involved in several processes, including centrosome separation; negative regulation of intracellular signal transduction; and positive regulation of metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval proventriculus; eye disc; larval central nervous system; larval enteroendocrine cell; and larval ventral nerve cord. Used to study congenital heart disease; metabolic dysfunction-associated steatotic liver disease; and syndromic intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to several human genes including UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubc6 in Genome Data Viewer
    Location:
    82E3-82E4; 3-47.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4948755..4952682, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (774477..778404, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45188 Neighboring gene small nuclear RNA U1 at 82Eb Neighboring gene Juvenile hormone binding protein 3 Neighboring gene Juvenile hormone binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6. Koken M, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 1902572, Free PMC Article
    2. Validating Candidate Congenital Heart Disease Genes in Drosophila. Zhu JY, et al. Bio Protoc, 2017 Jun 20. PMID 29276722, Free PMC Article
    3. A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response. Cai Q, et al. Cell Rep, 2022 Dec 13. PMID 36516751
    4. Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. White PM, et al. Genetics, 2017 Apr. PMID 28159754, Free PMC Article
    5. Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute. Jasti N, et al. Dev Genes Evol, 2020 Jul. PMID 32623522

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 6
    Names
    CG2013-PA
    CG2013-PC
    Ubc6-PA
    Ubc6-PC
    ubiquitin conjugating enzyme
    NP_001246916.1
    NP_524230.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4948755..4952682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079506.4 → NP_524230.2  ubiquitin conjugating enzyme 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524230.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25153, Q9VN70
      UniProtKB/TrEMBL
      A0A0B4K5Z5, D6W4U4
      Related
      FBpp0078490
      Conserved Domains (1) summary
      pfam00179
      Location:8 → 145
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001259987.3 → NP_001246916.1  ubiquitin conjugating enzyme 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25153, Q9VN70
      UniProtKB/TrEMBL
      A0A0B4K5Z5, D6W4U4
      Conserved Domains (1) summary
      pfam00179
      Location:8 → 145
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K5Z5 A0A0B4K5Z5
    P25153.2 P25153

    Gene LinkOut

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