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    Nepl9 Neprilysin-like 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl9provided by FlyBase
    Official Full Name
    Neprilysin-like 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0032613
    Locus tag
    Dmel_CG13283
    See related
    AllianceGenome:FB:FBgn0032613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13283; Dmel\CG13283
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl9 in Genome Data Viewer
    Location:
    36B2-36B2; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16835136..16837258, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16835136..16837258, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midway Neighboring gene Chromosome segregation 1 Neighboring gene Aspartyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Sarcolamban B Neighboring gene Sarcolamban A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Magny EG, et al. Science, 2013 Sep 6. PMID 23970561
    2. A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster. Holland C, et al. Genetics, 2011 Jun. PMID 21441212, Free PMC Article
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Functional roles for redox genes in ethanol sensitivity in Drosophila. Awofala AA, et al. Funct Integr Genomics, 2012 Jun. PMID 22430022
    5. First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory. Zarubin M, et al. PLoS One, 2021. PMID 34351964, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 9
    Names
    CG13283-PA
    Nepl9-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16835136..16837258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135971.2 → NP_609815.1  Neprilysin-like 9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4Y3, Q9VJH0
      Related
      FBpp0080482
      Conserved Domains (1) summary
      cl14813
      Location:579 → 642
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJH0 Q9VJH0

    Gene LinkOut

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