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    TM9SF4 Transmembrane 9 superfamily protein member 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TM9SF4provided by FlyBase
    Official Full Name
    Transmembrane 9 superfamily protein member 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0028541
    Locus tag
    Dmel_CG7364
    See related
    AllianceGenome:FB:FBgn0028541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00797.1; CG16861; CG7364; Dmel\CG7364; n(2)k07245; phg1
    Summary
    Involved in several processes, including defense response to Gram-negative bacterium; encapsulation of foreign target; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Is expressed in adult head and organism. Orthologous to human TM9SF4 (transmembrane 9 superfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TM9SF4 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13746952..13773905)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13746952..13773905)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nemuri Neighboring gene long non-coding RNA:CR45913 Neighboring gene long non-coding RNA:CR44846 Neighboring gene mir-1002 stem loop Neighboring gene mir-968 stem loop Neighboring gene antisense RNA:CR31845 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific host genes required for the killing of Klebsiella bacteria by phagocytes. Benghezal M, et al. Cell Microbiol, 2006 Jan. PMID 16367873
    2. The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila. Perrin J, et al. J Innate Immun, 2015. PMID 25139117, Free PMC Article
    3. Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. Pruvot B, et al. Immunogenetics, 2010 Oct. PMID 20820770
    4. TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis. Bergeret E, et al. J Cell Sci, 2008 Oct 15. PMID 18796536
    5. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing TM9SF4 prevents plasma membrane localization of PGRP-LC, whereas silencing TM9SF2 does not, which may account for the non-redundant role of TM9SF4 in phagocytosis of Gram-negative bacteria.
      Title: The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane 9 superfamily protein member 4
    Names
    CG7364-PA
    CG7364-PB
    TM9SF4-PA
    TM9SF4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13746952..13773905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298978.1 → NP_001285907.1  transmembrane 9 superfamily protein member 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3N6
      Conserved Domains (1) summary
      pfam02990
      Location:57 → 587
      EMP70; Endomembrane protein 70

    2. NM_135825.4 → NP_609669.1  transmembrane 9 superfamily protein member 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3N6
      Related
      FBpp0080109
      Conserved Domains (1) summary
      pfam02990
      Location:57 → 587
      EMP70; Endomembrane protein 70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3N6 Q9V3N6

    Gene LinkOut

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