U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ns1 Nucleostemin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42060, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ns1provided by FlyBase
    Official Full Name
    Nucleostemin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038473
    Locus tag
    Dmel_CG3983
    See related
    AllianceGenome:FB:FBgn0038473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3983; Dmel\CG3983; dmNS1; ns1; NS1
    Summary
    Enables ATP hydrolysis activity and GTPase activity. Involved in regulation of cell population proliferation; regulation of growth; and ribosomal large subunit biogenesis. Located in granular component. Is expressed in spermatozoon. Orthologous to several human genes including GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ns1 in Genome Data Viewer
    Location:
    89E11-89E11; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17070523..17072675, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12896245..12898397, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein associated with topo II related - 1 Neighboring gene Daughters against dpp Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene Keap1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes. Kearse MG, et al. Nucleus, 2013 May-Jun. PMID 23778934, Free PMC Article
    2. Knockdown of the Drosophila GTPase nucleostemin 1 impairs large ribosomal subunit biogenesis, cell growth, and midgut precursor cell maintenance. Rosby R, et al. Mol Biol Cell, 2009 Oct. PMID 19710426, Free PMC Article
    3. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
    4. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Falahati H, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115706, Free PMC Article
    5. Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress. Wang Y, et al. Chromosoma, 2017 Jun. PMID 27150106

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in granular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nucleostemin 1
    Names
    CG3983-PA
    Ns1-PA
    nucleostemin ortholog 1
    nucleostemin1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17070523..17072675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169742.3 → NP_732199.2  nucleostemin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732199.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V308, B6IDZ0, Q8MT06, Q9VEN7
      Related
      FBpp0082867
      Conserved Domains (5) summary
      cd00882
      Location:271 → 400
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cd04178
      Location:152 → 322
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:121 → 443
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08701
      Location:17 → 88
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
      cl21568
      Location:59 → 150
      SurA_N_3; SurA N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MT06.2 Q8MT06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools