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    mRpL49 mitochondrial ribosomal protein L49 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRpL49provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein L49provided by FlyBase
    Primary source
    FLYBASE:FBgn0030433
    Locus tag
    Dmel_CG4647
    See related
    AllianceGenome:FB:FBgn0030433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE35556; CG4647; Dmel\CG4647; MRP-L49; mRpl49
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in adult head. Orthologous to human MRPL49 (mitochondrial ribosomal protein L49). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpL49 in Genome Data Viewer
    Location:
    11D1-11D1; 1-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12907105..12907942)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12801138..12801975)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flavin adenine dinucleotide synthetase 1 Neighboring gene uncharacterized protein Neighboring gene BRMS1 transcriptional repressor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila radish gene encodes a protein required for anesthesia-resistant memory. Folkers E, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088531, Free PMC Article
    2. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
    3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
    4. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article
    5. The ribosomal protein genes and Minute loci of Drosophila melanogaster. Marygold SJ, et al. Genome Biol, 2007. PMID 17927810, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein L49
    Names
    CG4647-PA
    CG4647-PB
    mRpL49-PA
    mRpL49-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12907105..12907942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298241.1 → NP_001285170.1  mitochondrial ribosomal protein L49, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYI3
      UniProtKB/TrEMBL
      F3YDM8
      Conserved Domains (1) summary
      pfam05046
      Location:93 → 174
      Img2; Mitochondrial large subunit ribosomal protein (Img2)

    2. NM_132611.3 → NP_572839.1  mitochondrial ribosomal protein L49, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYI3
      UniProtKB/TrEMBL
      F3YDM8
      Related
      FBpp0073524
      Conserved Domains (1) summary
      pfam05046
      Location:93 → 174
      Img2; Mitochondrial large subunit ribosomal protein (Img2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F3YDM8 F3YDM8
    Q8SXZ9 Q8SXZ9
    Q9VYI3.1 Q9VYI3

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