Casp1 caspase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp1provided by MGI
Official Full Name: caspase 1provided by MGI
Primary source: MGI:MGI:96544
See related: Ensembl:ENSMUSG00000025888 AllianceGenome:MGI:96544
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ICE; Il1bc
Summary: Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of interleukin-1 beta production. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in several structures, including forelimb mesenchyme; knee joint; oocyte; small intestine; and telencephalon. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 2.2) and 13 other tissues See more
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (5298517..5307281)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (5298517..5307281)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3/Caspase-1 pathway.
Title: Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3/Caspase-1 pathway.
Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.
Title: Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice.
Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
Title: Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.
Title: Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.
NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.
Title: NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1.
miR-96-5p alleviates cerebral ischemia-reperfusion injury in mice by inhibiting pyroptosis via downregulating caspase 1.
Title: miR-96-5p alleviates cerebral ischemia-reperfusion injury in mice by inhibiting pyroptosis via downregulating caspase 1.
Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection.
Title: Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection.
Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.
Title: Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.
Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.
Title: Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.
CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1beta signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.
Title: CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (284)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Casp1 (e-PCR), detects polymorphism
- UniSTS:259198

Casp1 (e-PCR), detects polymorphism
- UniSTS:265644

Casp1 (e-PCR), detects polymorphism
- UniSTS:141228

Casp1 (e-PCR), detects polymorphism
- UniSTS:141229

PMC27008P1 (e-PCR)
- UniSTS:272372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AIM2 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytokine precursor processing	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in osmosensory signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in pattern recognition receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed necrotic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyroptotic inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AIM2 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AIM2 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of AIM2 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IPAF inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of NLRP1 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP1 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NLRP1 inflammasome complex	NAS Non-traceable Author Statement more info	PubMed
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP3 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP3 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protease inhibitor complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-1

Names: CASP-1; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45

NP_033937.2

EC 3.4.22.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009807.2 → NP_033937.2 caspase-1

See identical proteins and their annotated locations for NP_033937.2

Status: VALIDATED

Source sequence(s)

BC008152

Consensus CDS

CCDS22798.1

UniProtKB/Swiss-Prot

P29452

Related

ENSMUSP00000027015.6, ENSMUST00000027015.7

Conserved Domains (2) summary

smart00115
Location:152 → 400

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08325
Location:6 → 87

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins