Tnni1 troponin I1, slow skeletal type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnni1provided by RGD
Official Full Name: troponin I1, slow skeletal typeprovided by RGD
Primary source: RGD:621765
See related: EnsemblRapid:ENSRNOG00000009073 AllianceGenome:RGD:621765
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to act upstream of or within transition between fast and slow fiber and ventricular cardiac muscle tissue morphogenesis. Part of troponin complex. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1478.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49781529..49793385)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (47229217..47241640)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (52624856..52637297)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Title: Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
regular aerobic exercise appeared to have antioxidant effects in the muscle that reduced TNNI1 slow carbonylation and promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and TNNI1 expression for skeletal muscle contraction regulation
Title: Regular aerobic exercise-ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession.
Troponin I interaction with calcium and Troponin C in cardiac muscle
Title: The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR.
these results suggest that cTnI(R146G) and cTnI(R21C) blunt PKA modulation of activation and relaxation kinetics by prohibiting cardiac-specific N-terminal interaction with the cTnI inhibitory peptide.
Title: Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.
These findings suggest that altered TnI function, due to changes in the distribution of phosphorylated sites, is an early contributor to reduced contractility of the heart.
Title: Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation.
observed higher relative level of natural antisense RNA in neonatal cardiac fibroblasts compared to neonatal cardiomyocytes, pointing to a cell type-specific expression of sense and antisense RNA
Title: Cell type-specific expression of endogenous cardiac Troponin I antisense RNA in the neonatal rat heart.
The negative inotropic effect of HIV gp120 is mediated by a novel signaling pathway that begins with binding to a cardiac myocyte CXCR4 receptor, followed by phosphorylation of both p38 MAP kinase and Troponin I.
Title: CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120.
Study identifies tyrosine phosphorylation as a novel protein kinase Cdelta (PKCdelta) activation mechanism that modifies PKCdelta-dependent phosphorylation of cardiac troponin I.
Title: Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
This study highlights cellular contractile defects by cardiomyopathy mutant cTnIs that are allele and species dependent.
Title: Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants.
The goal here was to identify domain clusters and residues that confer troponin I isoform-specific myofilament Ca2+ and pH sensitivities of contraction.
Title: Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133325 (e-PCR)
- UniSTS:216608

TNNI1 (e-PCR)
- UniSTS:506439

D13Wox16 (e-PCR)
- UniSTS:518748

RH137504 (e-PCR)
- UniSTS:219592

RH142414 (e-PCR)
- UniSTS:231661

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in transition between fast and slow fiber	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin I, slow skeletal muscle

Names: troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017184.2 → NP_058880.2 troponin I, slow skeletal muscle

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P13413

UniProtKB/TrEMBL

F1LMC6

Related

ENSRNOP00000067933.3, ENSRNOT00000076054.4

Conserved Domains (1) summary

pfam00992
Location:15 → 146

Troponin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

49781529..49793385

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249862.5 → XP_006249924.1 troponin I, slow skeletal muscle isoform X1

Related

ENSRNOP00000012096.8, ENSRNOT00000012095.10

Conserved Domains (1) summary

pfam00992
Location:64 → 195

Troponin; Troponin