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    Hs3st4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 628779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st4provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 4provided by MGI
    Primary source
    MGI:MGI:1333792
    See related
    Ensembl:ENSMUSG00000078591 AllianceGenome:MGI:1333792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm6915
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Is expressed in ear; integumental system; and nervous system. Orthologous to human HS3ST4 (heparan sulfate-glucosamine 3-sulfotransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 5.4), CNS E18 (RPKM 4.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hs3st4 in Genome Data Viewer
    Location:
    7 F3; 7 67.56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (123581586..123998212)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123982366..124398989)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30335 Neighboring gene predicted gene, 23788 Neighboring gene predicted gene, 26974 Neighboring gene VISTA enhancer mm687 Neighboring gene STARR-seq mESC enhancer starr_20101 Neighboring gene RIKEN cDNA 4930551E15 gene Neighboring gene predicted gene, 25759 Neighboring gene STARR-seq mESC enhancer starr_20103 Neighboring gene STARR-seq mESC enhancer starr_20104 Neighboring gene STARR-seq mESC enhancer starr_20107 Neighboring gene predicted gene, 23168 Neighboring gene predicted gene, 57516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Determining heparan sulfate structure in the vicinity of specific sulfotransferase recognition sites by mass spectrometry. Wu ZL, et al. J Biol Chem, 2004 Jan 16. PMID 14602711
    2. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Qiu H, et al. Nat Methods, 2018 Nov. PMID 30377379, Free PMC Article
    3. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372
    4. Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity. Doyle DZ, et al. Proc Natl Acad Sci U S A, 2021 May 25. PMID 34011608, Free PMC Article
    5. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. Shworak NW, et al. J Biol Chem, 1999 Feb 19. PMID 9988767

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 4
    NP_001239001.1
    XP_006508167.1
    XP_030098720.1
    XP_030098722.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252072.2 → NP_001239001.1  heparan sulfate glucosamine 3-O-sulfotransferase 4

      Status: VALIDATED

      Source sequence(s)
      AC126278, AC151718, BQ177219, CJ154897
      Consensus CDS
      CCDS57584.1
      UniProtKB/TrEMBL
      D3YVV6
      Related
      ENSMUSP00000102045.2, ENSMUST00000106437.2
      Conserved Domains (1) summary
      pfam00685
      Location:190 → 427
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      123581586..123998212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242860.2 → XP_030098720.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X1

      Conserved Domains (1) summary
      cl21551
      Location:190 → 238
      Sulfotransfer_3; Sulfotransferase family

    2. XM_006508104.5 → XP_006508167.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X2

      Conserved Domains (1) summary
      pfam00685
      Location:32 → 204
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_030242862.1 → XP_030098722.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X3

      Conserved Domains (1) summary
      pfam00685
      Location:22 → 194
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. XR_003946536.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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