U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trmt5 tRNA methyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362754, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trmt5provided by RGD
    Official Full Name
    tRNA methyltransferase 5provided by RGD
    Primary source
    RGD:1306567
    See related
    EnsemblRapid:ENSRNOG00000007785 AllianceGenome:RGD:1306567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306567
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 68.7), Spleen (RPKM 55.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trmt5 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97702375..97723534, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91963558..91987660, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96164579..96171680, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene solute carrier family 38, member 6 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tRNA (guanine(37)-N1)-methyltransferase
    Names
    TRM5 tRNA methyltransferase 5 homolog
    tRNA (guanine-N(1)-)-methyltransferase
    tRNA methyltransferase 5 homolog
    NP_001383002.1
    NP_001383003.1
    XP_038968435.1
    XP_038968437.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396073.1NP_001383002.1  tRNA (guanine(37)-N1)-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HC55, F1LYK6
      Conserved Domains (1) summary
      COG2520
      Location:86461
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
    2. NM_001396074.1NP_001383003.1  tRNA (guanine(37)-N1)-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HC56, F1LYK6
      Related
      ENSRNOP00000010546.7, ENSRNOT00000010546.9
      Conserved Domains (1) summary
      COG2520
      Location:35410
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      97702375..97723534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112507.2XP_038968435.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU45, A0A8I5ZMD1
      Related
      ENSRNOP00000068961.1, ENSRNOT00000078190.3
      Conserved Domains (1) summary
      COG2520
      Location:86461
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
    2. XM_039112509.2XP_038968437.1  tRNA (guanine(37)-N1)-methyltransferase isoform X2

      Conserved Domains (1) summary
      COG2520
      Location:1244
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]