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    Ints4 integrator complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308837, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ints4provided by RGD
    Official Full Name
    integrator complex subunit 4provided by RGD
    Primary source
    RGD:1305036
    See related
    EnsemblRapid:ENSRNOG00000012552 AllianceGenome:RGD:1305036
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305036
    Summary
    Predicted to be involved in snRNA processing. Predicted to be located in nucleolus. Predicted to be part of integrator complex. Predicted to be active in nucleus. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 122.0), Thymus (RPKM 118.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints4 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161201284..161265042)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151790062..151853827)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162447692..162511350)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1, pseudogene 2 Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene adipogenesis associated, Mth938 domain containing Neighboring gene remodeling and spacing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191629.1 → NP_001178558.1  integrator complex subunit 4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ATK0, D3ZZQ6
      Related
      ENSRNOP00000016770.5, ENSRNOT00000016770.8
      Conserved Domains (3) summary
      COG1413
      Location:52 → 257
      HEAT; HEAT repeat [General function prediction only]
      pfam12755
      Location:199 → 256
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:200 → 222
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161201284..161265042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262797.1 → XP_063118867.1  integrator complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQI3
    Nucleotide Protein Strain
    Heading Accession and Version

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