Ankh ANKH inorganic pyrophosphate transport regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ankhprovided by RGD
Official Full Name: ANKH inorganic pyrophosphate transport regulatorprovided by RGD
Primary source: RGD:619925
See related: EnsemblRapid:ENSRNOG00000010960 AllianceGenome:RGD:619925
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ank; SLC61A1
Summary: Predicted to enable ATP transmembrane transporter activity; inorganic diphosphate transmembrane transporter activity; and phosphate transmembrane transporter activity. Predicted to be involved in several processes, including ATP export; cementum mineralization; and diphosphate metabolic process. Predicted to be located in membrane. Predicted to be active in extracellular region and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 420.7), Brain (RPKM 249.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (79883350..80011222)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (78153027..78280181)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (80131563..80256948)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work reveals the ANKH regulation of Wnt1 in vascular smooth muscle cells is essential for blocking vascular calcification (VC). Our findings may contribute to the development of medications that target Wnt signaling and/or ANKH to inhibit VC.
Title: Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression.
Phosphorylation of JNK promotes natural degeneration of cervical endplate chondrocytes, likely by down-regulating ANK expression
Title: JNK phosphorylation promotes natural degeneration of cervical endplate chondrocytes by down-regulating expression of ANK.
TNF-activated NF-kappaB promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion.
Title: Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression.
Results show that Cyclic Mechanical Tension (ICMT) induced the calcification and downregulation of ankh gene expression of end plate chondrocytes.
Title: Intermittent Cyclic Mechanical Tension-Induced Calcification and downregulation of ankh gene expression of end plate chondrocytes.
The effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-beta1 protein expression in rat endplate chondrocytes, were investigated.
Title: Effects of mechanical strain on ANK, ENPP1 and TGF-β1 expression in rat endplate chondrocytes in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130003 (e-PCR)
- UniSTS:213291

RH144292 (e-PCR)
- UniSTS:233537

BF390362 (e-PCR)
- UniSTS:249449

RH126477 (e-PCR)
- UniSTS:163185

RH138258 (e-PCR)
- UniSTS:220345

AU049423 (e-PCR)
- UniSTS:145870

BF403669 (e-PCR)
- UniSTS:246499

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inorganic diphosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables inorganic diphosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inorganic diphosphate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IEA Inferred from Electronic Annotation more info
involved_in ATP export	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cementum mineralization	IEA Inferred from Electronic Annotation more info
involved_in cementum mineralization	ISO Inferred from Sequence Orthology more info
involved_in diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	IEA Inferred from Electronic Annotation more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info
involved_in inorganic diphosphate transport	IEA Inferred from Electronic Annotation more info
involved_in inorganic diphosphate transport	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bone mineralization	TAS Traceable Author Statement more info	PubMed
involved_in response to sodium phosphate	IEA Inferred from Electronic Annotation more info
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mineralization regulator ANKH

Names: ATP carrier protein ANKH; ankylosis, progressive homolog; progressive ankylosis homolog; progressive ankylosis protein homolog; solute carrier family 61 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053714.2 → NP_446166.2 mineralization regulator ANKH

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P58366

Related

ENSRNOP00000090762.2, ENSRNOT00000104784.2

Conserved Domains (1) summary

pfam07260
Location:1 → 345

ANKH; Progressive ankylosis protein (ANKH)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

79883350..80011222

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281148.1 → XP_063137218.1 mineralization regulator ANKH isoform X1

UniProtKB/Swiss-Prot

P58366

UniProtKB/TrEMBL

A0A8I6AEF5
XM_063281149.1 → XP_063137219.1 mineralization regulator ANKH isoform X2

UniProtKB/Swiss-Prot

P58366
XM_063281150.1 → XP_063137220.1 mineralization regulator ANKH isoform X3

UniProtKB/Swiss-Prot

P58366

UniProtKB/TrEMBL

F1LN34

Related

ENSRNOP00000060060.4, ENSRNOT00000068484.4