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    Qrich1 glutamine-rich 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301004, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Qrich1provided by RGD
    Official Full Name
    glutamine-rich 1provided by RGD
    Primary source
    RGD:1311095
    See related
    EnsemblRapid:ENSRNOG00000025071 AllianceGenome:RGD:1311095
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311095
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in intracellular signal transduction; positive regulation of DNA-templated transcription; and positive regulation of apoptotic process. Predicted to act upstream of or within kidney development. Predicted to be located in nucleoplasm. Orthologous to human QRICH1 (glutamine rich 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 185.7), Testes (RPKM 161.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qrich1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118095435..118135001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109216900..109256472)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117305803..117346738)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene microRNA 3555 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator QRICH1
    Names
    glutamine-rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134532.1 → NP_001128004.1  transcriptional regulator QRICH1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A0A0G2JX16, A6I364, F1M4M7
      Related
      ENSRNOP00000059054.2, ENSRNOT00000064571.5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      cl00213
      Location:600 → 673
      DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118095435..118135001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265252.1 → XP_063121322.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46

    2. XM_006243745.5 → XP_006243807.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    3. XM_006243747.5 → XP_006243809.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    4. XM_063265253.1 → XP_063121323.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46

    5. XM_006243746.5 → XP_006243808.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Related
      ENSRNOP00000070097.3, ENSRNOT00000080778.3
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    6. XM_006243749.5 → XP_006243811.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    7. XM_063265251.1 → XP_063121321.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46

    8. XM_006243744.5 → XP_006243806.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Related
      ENSRNOP00000092802.1, ENSRNOT00000108928.2
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    9. XM_006243750.5 → XP_006243812.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
      Conserved Domains (2) summary
      cd01671
      Location:6 → 48
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:600 → 760
      DUF3504; Domain of unknown function (DUF3504)

    10. XM_063265250.1 → XP_063121320.1  transcriptional regulator QRICH1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX16, A0A8I6AW46
    Nucleotide Protein Strain
    Heading Accession and Version

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