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    Gsdmc2 gasdermin C2 [ Mus musculus (house mouse) ]

    Gene ID: 331063, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gsdmc2provided by MGI
    Official Full Name
    gasdermin C2provided by MGI
    Primary source
    MGI:MGI:2146102
    See related
    Ensembl:ENSMUSG00000056293 AllianceGenome:MGI:2146102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130023H10
    Summary
    Enables wide pore channel activity. Involved in intestinal epithelial cell development; pyroptotic inflammatory response; and type 2 immune response. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in gut and urinary system. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 227.0), colon adult (RPKM 40.2) and 1 other tissue See more
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    Genomic context

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    See Gsdmc2 in Genome Data Viewer
    Location:
    15 D1; 15 27.91 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63696177..63717042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63824328..63845193, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C Neighboring gene gasdermin pseudogene Neighboring gene gasdermin C-like 1 Neighboring gene gasdermin C3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Xi R, et al. Proc Natl Acad Sci U S A, 2021 Jul 27. PMID 34290141, Free PMC Article
    2. Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Fattinger SA, et al. Proc Natl Acad Sci U S A, 2023 Nov 28. PMID 37988464, Free PMC Article
    3. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798
    4. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables wide pore channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables wide pore channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestinal epithelial cell development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyroptotic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyroptotic inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in type 2 immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gasdermin-C2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168274.1 → NP_001161746.1  gasdermin-C2

      See identical proteins and their annotated locations for NP_001161746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC140673, AK033603
      Consensus CDS
      CCDS37087.1
      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Related
      ENSMUSP00000140487.2, ENSMUST00000188691.2
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    2. NM_177912.4 → NP_808580.2  gasdermin-C2

      See identical proteins and their annotated locations for NP_808580.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC140673, AK033603
      Consensus CDS
      CCDS37087.1
      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Related
      ENSMUSP00000141066.2, ENSMUST00000188404.7
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      63696177..63717042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521097.4 → XP_006521160.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_006521160.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    2. XM_011245674.3 → XP_011243976.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243976.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    3. XM_011245670.3 → XP_011243972.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243972.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    4. XM_011245667.3 → XP_011243969.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243969.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    5. XM_011245676.3 → XP_011243978.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243978.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    6. XM_011245673.3 → XP_011243975.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243975.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    7. XM_011245668.3 → XP_011243970.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243970.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    8. XM_006521098.4 → XP_006521161.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_006521161.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    9. XM_011245677.3 → XP_011243979.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243979.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    10. XM_011245672.3 → XP_011243974.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243974.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    11. XM_011245671.3 → XP_011243973.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243973.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    12. XM_011245675.3 → XP_011243977.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243977.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    13. XM_011245669.3 → XP_011243971.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_011243971.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    14. XM_006521096.4 → XP_006521159.1  gasdermin-C2 isoform X1

      See identical proteins and their annotated locations for XP_006521159.1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain

    15. XM_030248612.1 → XP_030104472.1  gasdermin-C2 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHK6, Q2KHK8, Q8CC94
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 232
      Gasdermin; Gasdermin family
      pfam17708
      Location:272 → 441
      Gasdermin_C; Gasdermin PUB domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KHK6.2 GenPept UniProtKB/Swiss-Prot:Q2KHK6

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