Wdr75 WD repeat domain 75 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr75provided by MGI
Official Full Name: WD repeat domain 75provided by MGI
Primary source: MGI:MGI:1920924
See related: Ensembl:ENSMUSG00000025995 AllianceGenome:MGI:1920924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300003A18Rik; 2410118I19Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in pancreas epithelium. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.4), limb E14.5 (RPKM 8.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 23.87 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (45834313..45862798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (45795153..45823638)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126194 (e-PCR)
- UniSTS:162902

NoName (e-PCR)
- UniSTS:236426

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing protein 75

Names: U3 small nucleolar RNA-associated protein 17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028599.3 → NP_082875.1 WD repeat-containing protein 75

See identical proteins and their annotated locations for NP_082875.1

Status: VALIDATED

Source sequence(s)

AK152412, AK163221, CD541304, DV648013

Consensus CDS

CCDS14932.1

UniProtKB/Swiss-Prot

Q08EC1, Q3U821

UniProtKB/TrEMBL

Q3TQZ0

Related

ENSMUSP00000027139.9, ENSMUST00000027139.15

Conserved Domains (3) summary

COG2319
Location:23 → 319

WD40; WD40 repeat [General function prediction only]

sd00039
Location:60 → 98

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 313

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...