G6pdx glucose-6-phosphate dehydrogenase X-linked [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G6pdxprovided by MGI
Official Full Name: glucose-6-phosphate dehydrogenase X-linkedprovided by MGI
Primary source: MGI:MGI:105979
See related: Ensembl:ENSMUSG00000031400 AllianceGenome:MGI:105979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G28A; G6pd; Gpdx
Summary: Enables glucose-6-phosphate dehydrogenase activity and identical protein binding activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within several processes, including NADP biosynthetic process; erythrocyte development; and maintenance of blood vessel diameter homeostasis by renin-angiotensin. Is active in cytosol. Is expressed in several structures, including brain; genitourinary system; immune system; liver; and mammary gland. Used to study favism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 89.0), genital fat pad adult (RPKM 75.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 38.0 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73453089..73472486, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74409483..74428880, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brucella induced upregulation of NO promote macrophages glycolysis through the NF-kappaB/G6PD pathway.
Title: Brucella induced upregulation of NO promote macrophages glycolysis through the NF-κB/G6PD pathway.
FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis.
Title: FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis.
Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II.
Title: Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II.
G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation.
Title: G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation.
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function.
Title: Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function.
Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life.
Title: Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life.
Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.
Title: Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.
G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
Title: G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
These results demonstrated that the miR-206-G6PD pathway suppresses muscle cell proliferation, and these findings may facilitate the treatment of muscle diseases.
Title: MicroRNA-206 regulates cell proliferation by targeting G6PD in skeletal muscle.
High glucose induces ubiquitination of G6PD by VHL E3 ubiquitin ligase, which leads to ROS accumulation and podocyte injury.
Title: High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Radiation induced (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462521 (e-PCR)
- UniSTS:181300

PMC85812P2 (e-PCR)
- UniSTS:273495

NoName (e-PCR)
- UniSTS:491414

UniSTS:256936 (e-PCR)
- UniSTS:256936

G6pdx (e-PCR), detects polymorphism
- UniSTS:256936

Z11911 (e-PCR)
- UniSTS:125912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose binding	ISO Inferred from Sequence Orthology more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within NADP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NADPH regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein glutathionylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pentose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pentose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt, oxidative branch	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribose phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose-6-phosphate 1-dehydrogenase X

NP_032088.1

EC 1.1.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008062.3 → NP_032088.1 glucose-6-phosphate 1-dehydrogenase X

See identical proteins and their annotated locations for NP_032088.1

Status: VALIDATED

Source sequence(s)

AW489257, BC075663

Consensus CDS

CCDS30232.1

UniProtKB/Swiss-Prot

Q00612

UniProtKB/TrEMBL

Q3TNL1, Q790Y8

Related

ENSMUSP00000004327.5, ENSMUST00000004327.11

Conserved Domains (3) summary

TIGR00871
Location:30 → 506

zwf; glucose-6-phosphate 1-dehydrogenase

pfam00479
Location:35 → 209

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:212 → 503

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain