Kmt2a lysine (K)-specific methyltransferase 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kmt2aprovided by MGI
Official Full Name: lysine (K)-specific methyltransferase 2Aprovided by MGI
Primary source: MGI:MGI:96995
See related: Ensembl:ENSMUSG00000002028 AllianceGenome:MGI:96995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRX; Mll; All1; Mll1; ALL-1; Cxxc7; HTRX1; mKIAA4050; 6430520K01
Summary: Enables DNA binding activity; chromatin binding activity; and histone H3K4 methyltransferase activity. Involved in circadian regulation of gene expression; definitive hemopoiesis; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including peptidyl-lysine monomethylation; spleen development; and visual learning. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; nervous system; retina; and trunk mesenchyme. Used to study acute lymphoblastic leukemia; acute myeloid leukemia; and leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; myelofibrosis; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 13.7), spleen adult (RPKM 10.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44714652..44793492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44803355..44881352, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells.
Title: The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells.
LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis.
Title: LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis.
MLL1 regulates cytokine-driven cell migration and metastasis.
Title: MLL1 regulates cytokine-driven cell migration and metastasis.
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma.
Title: Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma.
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Title: The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2.
Title: Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Title: The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
MLL1 is required for maintenance of intestinal stem cells.
Title: MLL1 is required for maintenance of intestinal stem cells.
Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3.
Title: Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3.
[Leukemogenic pathway of infant leukemia with MLL fusion].
Title: [Leukemogenic pathway of infant leukemia with MLL fusion].

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (26) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mll (e-PCR), detects polymorphism
- UniSTS:143874

Mll1 (e-PCR), detects polymorphism
- UniSTS:143875

PMC27946P1 (e-PCR)
- UniSTS:272393

MARC_12741-12742:1029349377:1 (e-PCR)
- UniSTS:267437

L17069 (e-PCR)
- UniSTS:124876

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K4 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K4 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 trimethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info
enables unmethylated CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA methylation-dependent heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-lysine monomethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to potassium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spleen development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase 2A

Names: cysteine methyltransferase KMT2A; histone-lysine N-methyltransferase MLL; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax Drosophila; zinc finger protein HRX

NP_001344478.1

EC 2.1.1.364

XP_006510191.1

EC 2.1.1.364

XP_011240744.1

EC 2.1.1.364

XP_011240745.1

EC 2.1.1.364

XP_011240746.1

EC 2.1.1.364

XP_030100077.1

EC 2.1.1.364

XP_036010712.1

EC 2.1.1.364

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357549.2 → NP_001344478.1 histone-lysine N-methyltransferase 2A

Status: VALIDATED

Source sequence(s)

AC061963, AC142113, AC166048

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Related

ENSMUSP00000110337.2, ENSMUST00000114689.8

Conserved Domains (10) summary

cd05493
Location:1649 → 1779

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3666 → 3749

FYRC; FY-rich domain, C-terminal region

smart00317
Location:3828 → 3948

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1529

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1567 → 1626

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1873 → 1985

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05964
Location:2026 → 2073

FYRN; F/Y-rich N-terminus

cl25496
Location:3152 → 3361

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44714652..44793492 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242443.4 → XP_011240745.1 histone-lysine N-methyltransferase 2A isoform X2

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Conserved Domains (10) summary

cd05493
Location:1648 → 1778

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3665 → 3748

FYRC; FY-rich domain, C-terminal region

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1528

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1566 → 1625

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1872 → 1984

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:3151 → 3360

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:2025 → 2072

FYRN; F/Y-rich N-terminus

cd19170
Location:3812 → 3965

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
XM_030244217.2 → XP_030100077.1 histone-lysine N-methyltransferase 2A isoform X4

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Conserved Domains (10) summary

cd05493
Location:1646 → 1776

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3662 → 3745

FYRC; FY-rich domain, C-terminal region

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1529

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1567 → 1623

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1869 → 1981

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:3148 → 3357

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:2022 → 2069

FYRN; F/Y-rich N-terminus

cd19170
Location:3809 → 3962

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
XM_006510128.4 → XP_006510191.1 histone-lysine N-methyltransferase 2A isoform X3

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Conserved Domains (10) summary

cd05493
Location:1646 → 1776

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3663 → 3746

FYRC; FY-rich domain, C-terminal region

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1529

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1567 → 1623

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1870 → 1982

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:3149 → 3358

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:2023 → 2070

FYRN; F/Y-rich N-terminus

cd19170
Location:3810 → 3963

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
XM_011242442.4 → XP_011240744.1 histone-lysine N-methyltransferase 2A isoform X1

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Conserved Domains (10) summary

cd05493
Location:1649 → 1779

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3665 → 3748

FYRC; FY-rich domain, C-terminal region

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1529

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1567 → 1626

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1872 → 1984

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:3151 → 3360

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:2025 → 2072

FYRN; F/Y-rich N-terminus

cd19170
Location:3812 → 3965

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
XM_036154819.1 → XP_036010712.1 histone-lysine N-methyltransferase 2A isoform X6

Conserved Domains (9) summary

cd05493
Location:443 → 573

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:2460 → 2543

FYRC; FY-rich domain, C-terminal region

cd15588
Location:226 → 272

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:274 → 323

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:361 → 420

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:667 → 779

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:1946 → 2155

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd19170
Location:2607 → 2760

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins

pfam05964
Location:820 → 867

FYRN; F/Y-rich N-terminus
XM_011242444.4 → XP_011240746.1 histone-lysine N-methyltransferase 2A isoform X5

UniProtKB/Swiss-Prot

E9QNE7, P55200, Q3UEU1, Q3USE7

Conserved Domains (9) summary

cd05493
Location:1649 → 1779

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:3666 → 3749

FYRC; FY-rich domain, C-terminal region

cd15588
Location:1432 → 1478

PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15590
Location:1480 → 1529

PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15592
Location:1567 → 1626

PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)

cd15693
Location:1873 → 1985

ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)

pfam05109
Location:3152 → 3361

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam02008
Location:1144 → 1191

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:2026 → 2073

FYRN; F/Y-rich N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081049.1: Suppressed sequence

Description

NM_001081049.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.