QRFPR pyroglutamylated RFamide peptide receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: QRFPRprovided by HGNC
Official Full Name: pyroglutamylated RFamide peptide receptorprovided by HGNC
Primary source: HGNC:HGNC:15565
See related: Ensembl:ENSG00000186867 MIM:606925; AllianceGenome:HGNC:15565
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AQ27; GPR103; SP9155
Summary: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 4q27

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (121328642..121381018, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (124632974..124685273, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (122249797..122302173, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
Title: The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
Title: N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
Title: Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
The expression of both QRFP and GPR103 at the gene and protein level was higher in human prostate cancer tissue samples compared to control and benign prostatic hyperplasia samples.
Title: Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer.
The study represents the first to use WES in multiplex families for preeclampsia and identifies two novel genes (QRFPR and C1orf35) not previously associated with preeclampsia and find nominal association of rs34270076 with protein levels.
Title: Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes.
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
Title: Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
Title: GPR103b functions in the peripheral regulation of adipogenesis.
characterization and tissue distribution of SP9155 (GPR103) ligand
Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156606P3 (e-PCR)
- UniSTS:271410

sY3084 (e-PCR)
- UniSTS:515126

SHGC-148097 (e-PCR)
- UniSTS:176191

NoName (e-PCR)
- UniSTS:483449

G20706 (e-PCR)
- UniSTS:44153

RH41058 (e-PCR)
- UniSTS:88516

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pyroglutamylated RF-amide peptide receptor

Names: G-protein coupled receptor 103; QRFP receptor; orexigenic neuropeptide QRFP receptor; peptide P518 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198179.3 → NP_937822.2 pyroglutamylated RF-amide peptide receptor

See identical proteins and their annotated locations for NP_937822.2

Status: VALIDATED

Source sequence(s)

AB109629, AC093867, BG169612, DA461055

Consensus CDS

CCDS3719.1

UniProtKB/Swiss-Prot

Q96P65

UniProtKB/TrEMBL

G4XH69

Related

ENSP00000377948.2, ENST00000394427.3

Conserved Domains (1) summary

pfam00001
Location:62 → 332

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

121328642..121381018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008693.3 → XP_016864182.1 pyroglutamylated RF-amide peptide receptor isoform X1

UniProtKB/TrEMBL

F2Z3L3

Related

ENSP00000423369.1, ENST00000507331.5

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 187

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily