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    Lasp lasp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Laspprovided by FlyBase
    Official Full Name
    laspprovided by FlyBase
    Primary source
    FLYBASE:FBgn0063485
    Locus tag
    Dmel_CG3849
    See related
    AllianceGenome:FB:FBgn0063485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-73Bd; cDNA B; CG3849; Dmel\CG3849; lasp
    Summary
    Enables actin binding activity. Involved in several processes, including cellularization; myofibril assembly; and positive regulation of pole plasm oskar mRNA localization. Located in focal adhesion; sarcomere; and sperm individualization complex. Is expressed in several structures, including adult brain; adult gnathal ganglion; adult head; germline cell; and somatic cell of ovariole. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lasp in Genome Data Viewer
    Location:
    73B6-73C1; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16676406..16711677, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16669506..16704777, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) zeta Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45179 Neighboring gene long non-coding RNA:CR45897 Neighboring gene uncharacterized protein Neighboring gene Disabled Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LIM and SH3 protein 1 (LASP-1): A novel link between the slit membrane and actin cytoskeleton dynamics in podocytes. Lepa C, et al. FASEB J, 2020 Apr. PMID 32086849
    2. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development. Pollitt SL, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997597, Free PMC Article
    3. Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila. Laurinyecz B, et al. Open Biol, 2016 Jan. PMID 26791243, Free PMC Article
    4. The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo. Suyama R, et al. Development, 2009 Jan. PMID 19036801
    5. Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization. Lee S, et al. Mech Dev, 2008 Sep-Oct. PMID 18655828

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lasp, the only member of the nebulin family in Drosophila melanogaster, acts at two distinct sites in the sarcomere and controls thin filament length with just two nebulin repeats.
      Title: The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils.
    2. The Drosophila homolog of mammalian Lasp1 protein, an actin-binding protein previously implicated in cell migration in vertebrate cell culture, contributes to the accumulation of Oskar protein at the posterior pole of the embryo.
      Title: The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo.
    3. Lasp functions together with integrins in hub cells to anchor the stem cell niche.
      Title: Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole cell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myofibril size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm individualization complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lasp
    Names
    CG3849-PA
    CG3849-PB
    CG3849-PC
    CG3849-PD
    Lasp-PA
    Lasp-PB
    Lasp-PC
    Lasp-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16676406..16711677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168681.4 → NP_730192.2  lasp, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730192.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q59E31, Q8I7C3, Q9VV91
      Conserved Domains (4) summary
      smart00227
      Location:97 → 127
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 57
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:600 → 654
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:68 → 94
      Nebulin; Nebulin repeat

    2. NM_001259870.2 → NP_001246799.1  lasp, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH3
      Conserved Domains (4) summary
      smart00227
      Location:97 → 127
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 57
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:225 → 279
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:68 → 94
      Nebulin; Nebulin repeat

    3. NM_140655.3 → NP_648912.2  lasp, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648912.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7C3
      Related
      FBpp0075109
      Conserved Domains (4) summary
      smart00227
      Location:97 → 127
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 57
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:447 → 501
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:68 → 94
      Nebulin; Nebulin repeat

    4. NM_001259869.2 → NP_001246798.1  lasp, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDA6
      Conserved Domains (4) summary
      smart00227
      Location:97 → 127
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 57
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11789
      Location:579 → 633
      SH3_Nebulin_family_C; C-terminal Src Homology 3 domain of the Nebulin family of proteins
      pfam00880
      Location:68 → 94
      Nebulin; Nebulin repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDA6 M9NDA6
    M9NFH3 M9NFH3
    Q8I7C3.2 Q8I7C3

    Gene LinkOut

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