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    CG11089 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42973, updated on 4-Jan-2025

    Summary

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    Official Symbol
    CG11089provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039241
    Locus tag
    Dmel_CG11089
    See related
    AllianceGenome:FB:FBgn0039241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153761_at; atic; BEST:GH11240; CT30991; Dmel\CG11089
    Summary
    Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in wound healing. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See CG11089 in Genome Data Viewer
    Location:
    96B2-96B2; 3-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24877045..24881478)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20702767..20707200)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cyclin B3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
    2. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
    3. Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster. Wilinski D, et al. Nat Commun, 2019 Sep 6. PMID 31492856, Free PMC Article
    4. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Tufi R, et al. Nat Cell Biol, 2014 Feb. PMID 24441527, Free PMC Article
    5. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables IMP cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11089-PA
    CG11089-PB
    NP_001189286.1
    NP_651305.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24877045..24881478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143048.2 → NP_651305.1  uncharacterized protein Dmel_CG11089, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC18
      Related
      FBpp0084087
      Conserved Domains (3) summary
      PRK07106
      Location:201 → 590
      PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
      COG0138
      Location:5 → 590
      PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
      cd01421
      Location:5 → 191
      IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...

    2. NM_001202357.1 → NP_001189286.1  uncharacterized protein Dmel_CG11089, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC18
      Conserved Domains (3) summary
      PRK07106
      Location:201 → 590
      PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
      COG0138
      Location:5 → 590
      PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
      cd01421
      Location:5 → 191
      IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RT1 Q95RT1
    Q9VC18 Q9VC18

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