Trib2 tribbles pseudokinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Trib2provided by RGD
Full Name: tribbles pseudokinase 2provided by RGD
Primary source: RGD:1564451
See related: EnsemblRapid:ENSRNOG00000004110 AllianceGenome:RGD:1564451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564451
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; enzyme binding activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in negative regulation of fat cell differentiation; negative regulation of interleukin-10 production; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 209.8), Kidney (RPKM 149.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (44274762..44299139, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (38545971..38570349, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (41016722..41040972, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of tribbles homolog 2 in vascular smooth muscle cell proliferation.
Title: The role of tribbles homolog 2 in vascular smooth muscle cell proliferation.
The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction.
Title: Anti-Tribbles Pseudokinase 2 (TRIB2)-Immunization Modulates Hypocretin/Orexin Neuronal Functions.
TRB2 plays important roles in the pathogenesis of diabetic-2 large artery complications at early stage, and these effects may be modulated by miR-98
Title: Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat.

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General gene information

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Markers

Trib2 (e-PCR), detects polymorphism
- UniSTS:525617

AW319517 (e-PCR)
- UniSTS:180368

RH132990 (e-PCR)
- UniSTS:216273

D6Rat96 (e-PCR)
- UniSTS:119004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables nucleotide binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tribbles homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108015.3 → NP_001101485.2 tribbles homolog 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8J8XB91, A6HAS1

Related

ENSRNOP00000005774.6, ENSRNOT00000005774.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

44274762..44299139 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112192.2 → XP_038968120.1 tribbles homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8J8XB91, A6HAS1

Conserved Domains (1) summary

cd14022
Location:67 → 308

PK_TRB2; Pseudokinase domain of Tribbles Homolog 2
XM_039112193.2 → XP_038968121.1 tribbles homolog 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:67 → 187

PKc_like; Protein Kinases, catalytic domain
XM_039112194.2 → XP_038968122.1 tribbles homolog 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:67 → 187

PKc_like; Protein Kinases, catalytic domain