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    Arl2bp ARF like GTPase 2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498910, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl2bpprovided by RGD
    Official Full Name
    ARF like GTPase 2 binding proteinprovided by RGD
    Primary source
    RGD:1561471
    See related
    EnsemblRapid:ENSRNOG00000016991 AllianceGenome:RGD:1561471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in maintenance of protein location in nucleus and positive regulation of tyrosine phosphorylation of STAT protein. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in retinitis pigmentosa with or without situs inversus. Orthologous to human ARL2BP (ARF like GTPase 2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 388.6), Kidney (RPKM 321.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl2bp in Genome Data Viewer
    Location:
    19p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10342895..10352529, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10336921..10346555, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10753670..10763247, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon CAG) 8 Neighboring gene plasmolipin Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene proteasome activator subunit 3 interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arl2 and Arl3 regulate different microtubule-dependent processes. Zhou C, et al. Mol Biol Cell, 2006 May. PMID 16525022, Free PMC Article
    2. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. Sharer JD, et al. Mol Biol Cell, 2002 Jan. PMID 11809823, Free PMC Article
    3. BART is essential for nuclear retention of STAT3. Muromoto R, et al. Int Immunol, 2008 Mar. PMID 18234692
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of protein location in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 2-binding protein
    Names
    ADP-ribosylation factor like GTPase 2 binding protein
    ADP-ribosylation factor-like 2 binding protein
    ARF-like 2-binding protein
    binder of ARF2 protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024906.2 → NP_001020077.1  ADP-ribosylation factor-like protein 2-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001020077.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GJE6, A6JY54
      Conserved Domains (1) summary
      pfam11527
      Location:1 → 100
      ARL2_Bind_BART; The ARF-like 2 binding protein BART

    2. NM_001399077.1 → NP_001386006.1  ADP-ribosylation factor-like protein 2-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q4V8C5
      UniProtKB/TrEMBL
      A0A8I6GJE6, A6JY53
      Related
      ENSRNOP00000023455.6, ENSRNOT00000023455.7
      Conserved Domains (1) summary
      pfam11527
      Location:22 → 132
      ARL2_Bind_BART; The ARF-like 2 binding protein BART

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10342895..10352529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255121.5 → XP_006255183.1  ADP-ribosylation factor-like protein 2-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJE6
      Conserved Domains (1) summary
      pfam11527
      Location:14 → 121
      ARL2_Bind_BART; The ARF-like 2 binding protein BART

    2. XM_039097917.2 → XP_038953845.1  ADP-ribosylation factor-like protein 2-binding protein isoform X2

      UniProtKB/TrEMBL
      A6JY56
      Conserved Domains (1) summary
      pfam11527
      Location:1 → 88
      ARL2_Bind_BART; The ARF-like 2 binding protein BART

    3. XM_039097918.2 → XP_038953846.1  ADP-ribosylation factor-like protein 2-binding protein isoform X3

    RNA

    1. XR_005496680.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8C5.2 GenPept UniProtKB/Swiss-Prot:Q4V8C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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