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    Cd226 CD226 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307199, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cd226provided by RGD
    Official Full Name
    CD226 moleculeprovided by RGD
    Primary source
    RGD:1311513
    See related
    EnsemblRapid:ENSRNOG00000038197 AllianceGenome:RGD:1311513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of immune response; and positive regulation of mast cell activation. Predicted to act upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 94.0), Thymus (RPKM 74.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd226 in Genome Data Viewer
    Location:
    18q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84723330..84819836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82449924..82545107)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (86299392..86394772)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483073 Neighboring gene snRNA-activating protein complex subunit 5-like Neighboring gene prothymosin alpha like 3 Neighboring gene docking protein 6 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese. Liu C, et al. Can J Neurol Sci, 2012 Jul. PMID 22728856
    2. Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. Tahara-Hanaoka S, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752754
    3. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Chan CJ, et al. Nat Immunol, 2014 May. PMID 24658051
    4. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. Bottino C, et al. J Exp Med, 2003 Aug 18. PMID 12913096, Free PMC Article
    5. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. Bachelet I, et al. J Biol Chem, 2006 Sep 15. PMID 16831868

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. his study showed that CD226 Gly307Ser may correlate with risk of neuromyelitis optica in Southern Han Chinese.
      Title: CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD226 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107370.1 → NP_001100840.1  CD226 antigen precursor

      See identical proteins and their annotated locations for NP_001100840.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474021
      UniProtKB/TrEMBL
      A6K5P0, D3ZS97
      Related
      ENSRNOP00000054956.2, ENSRNOT00000058152.5
      Conserved Domains (3) summary
      cd05889
      Location:44 → 141
      Ig1_DNAM-1_like; First immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226) and similar proteins
      smart00410
      Location:152 → 255
      IG_like; Immunoglobulin like
      cl11960
      Location:151 → 239
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      84723330..84819836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096759.2 → XP_038952687.1  CD226 antigen isoform X1

      UniProtKB/TrEMBL
      A6K5P1
      Related
      ENSRNOP00000111825.1, ENSRNOT00000172632.1
      Conserved Domains (1) summary
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

    2. XM_006255028.5 → XP_006255090.1  CD226 antigen isoform X1

      See identical proteins and their annotated locations for XP_006255090.1

      UniProtKB/TrEMBL
      A6K5P1
      Conserved Domains (1) summary
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

    3. XM_006255031.5 → XP_006255093.1  CD226 antigen isoform X1

      See identical proteins and their annotated locations for XP_006255093.1

      UniProtKB/TrEMBL
      A6K5P1
      Conserved Domains (1) summary
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

    4. XM_039096758.2 → XP_038952686.1  CD226 antigen isoform X1

      UniProtKB/TrEMBL
      A6K5P1
      Conserved Domains (1) summary
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

    5. XM_063277286.1 → XP_063133356.1  CD226 antigen isoform X1

      UniProtKB/TrEMBL
      A6K5P1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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