Zp4 zona pellucida glycoprotein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zp4provided by RGD
Official Full Name: zona pellucida glycoprotein 4provided by RGD
Primary source: RGD:628708
See related: EnsemblRapid:ENSRNOG00000027506 AllianceGenome:RGD:628708
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zp-4
Summary: Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in several processes, including acrosomal vesicle exocytosis; binding activity of sperm to zona pellucida; and negative regulation of binding activity of sperm to zona pellucida. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 2.1), Uterus (RPKM 1.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17q12.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (63697147..63703700, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (59005649..59012202, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (65497359..65503912)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zp4 is completely dispensable for fertility in female ratsdagger.
Title: Zp4 is completely dispensable for fertility in female rats†.
Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger.
Title: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats†.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables acrosin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of egg coat	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in prevention of polyspermy	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in egg coat	IBA Inferred from Biological aspect of Ancestor more info
located_in egg coat	IEA Inferred from Electronic Annotation more info
located_in egg coat	ISO Inferred from Sequence Orthology more info
located_in egg coat	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zona pellucida sperm-binding protein 4

Names: zona pellucida 4; zona pellucida B glycoprotein; zona pellucida protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172330.3 → NP_758833.2 zona pellucida sperm-binding protein 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q8CH34

UniProtKB/TrEMBL

F1LP51

Related

ENSRNOP00000031597.4, ENSRNOT00000038938.5

Conserved Domains (2) summary

pfam00088
Location:150 → 191

Trefoil; Trefoil (P-type) domain

pfam00100
Location:198 → 469

Zona_pellucida; Zona pellucida-like domain