Lgi2 leucine-rich repeat LGI family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgi2provided by RGD
Official Full Name: leucine-rich repeat LGI family, member 2provided by RGD
Primary source: RGD:1310391
See related: EnsemblRapid:ENSRNOG00000066201 AllianceGenome:RGD:1310391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. Orthologous to human LGI2 (leucine rich repeat LGI family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 115.6), Muscle (RPKM 79.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (62628746..62656231)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (58415965..58443450)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (60764325..60791809)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat LGI family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107219.2 → NP_001100689.2 leucine-rich repeat LGI family member 2 precursor

See identical proteins and their annotated locations for NP_001100689.2

Status: PROVISIONAL

Source sequence(s)

BC168885

UniProtKB/TrEMBL

B5DF14

Related

ENSRNOP00000094580.1, ENSRNOT00000097229.2

Conserved Domains (4) summary

TIGR00864
Location:137 → 212

PCC; polycystin cation channel protein

sd00031
Location:108 → 131

LRR_1; leucine-rich repeat [structural motif]

pfam03736
Location:263 → 301

EPTP; EPTP domain

pfam13855
Location:107 → 166

LRR_8; Leucine rich repeat