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    Rexo5 RNA exonuclease 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309036, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rexo5provided by RGD
    Official Full Name
    RNA exonuclease 5provided by RGD
    Primary source
    RGD:1305412
    See related
    EnsemblRapid:ENSRNOG00000014513 AllianceGenome:RGD:1305412
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Exnef; RGD1305412; 2610020h08rik
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human REXO5 (RNA exonuclease 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 91.6), Thymus (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rexo5 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183599954..183698433)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174168633..174264526)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189549960..189643698)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene uncharacterized LOC134483776 Neighboring gene THUMP domain containing 1 Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene dynein, axonemal, heavy chain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156803

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 5
    Names
    exonuclease NEF-sp
    putative RNA exonuclease NEF-sp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079706.1 → NP_001073174.1  RNA exonuclease 5

      See identical proteins and their annotated locations for NP_001073174.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128775
      UniProtKB/Swiss-Prot
      A1A5R7
      UniProtKB/TrEMBL
      A0A0G2K6L8, A6I8N3
      Related
      ENSRNOP00000073863.3, ENSRNOT00000083153.3
      Conserved Domains (2) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:489 → 559
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183599954..183698433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263680.1 → XP_063119750.1  RNA exonuclease 5 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K6L8

    2. XM_039078635.2 → XP_038934563.1  RNA exonuclease 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Conserved Domains (2) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:508 → 578
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_063263675.1 → XP_063119745.1  RNA exonuclease 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6L8

    4. XM_063263692.1 → XP_063119762.1  RNA exonuclease 5 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Related
      ENSRNOP00000019654.7, ENSRNOT00000019654.9

    5. XM_063263677.1 → XP_063119747.1  RNA exonuclease 5 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6L8

    6. XM_039078643.2 → XP_038934571.1  RNA exonuclease 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Conserved Domains (2) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:508 → 578
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_063263687.1 → XP_063119757.1  RNA exonuclease 5 isoform X5

      UniProtKB/Swiss-Prot
      A1A5R7
      UniProtKB/TrEMBL
      A0A0G2K6L8, A6I8N3

    8. XM_017589228.3 → XP_017444717.1  RNA exonuclease 5 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Conserved Domains (4) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:252 → 388
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cd12273
      Location:508 → 578
      RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
      cl17169
      Location:604 → 674
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_008759760.4 → XP_008757982.1  RNA exonuclease 5 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Conserved Domains (4) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:252 → 388
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cd12273
      Location:508 → 578
      RRM1_NEFsp; RNA recognition motif 1 in vertebrate putative RNA exonuclease NEF-sp
      cl17169
      Location:604 → 674
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_063263682.1 → XP_063119752.1  RNA exonuclease 5 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K6L8

    11. XM_063263722.1 → XP_063119792.1  RNA exonuclease 5 isoform X14

    12. XM_063263715.1 → XP_063119785.1  RNA exonuclease 5 isoform X14

    13. XM_039078737.2 → XP_038934665.1  RNA exonuclease 5 isoform X11

      Conserved Domains (1) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins

    14. XM_063263729.1 → XP_063119799.1  RNA exonuclease 5 isoform X14

    15. XM_063263690.1 → XP_063119760.1  RNA exonuclease 5 isoform X5

      UniProtKB/Swiss-Prot
      A1A5R7
      UniProtKB/TrEMBL
      A0A0G2K6L8, A6I8N3

    16. XM_039078729.1 → XP_038934657.1  RNA exonuclease 5 isoform X9

      Conserved Domains (2) summary
      cd06145
      Location:1 → 138
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:275 → 345
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. XM_063263711.1 → XP_063119781.1  RNA exonuclease 5 isoform X12

    18. XM_063263738.1 → XP_063119808.1  RNA exonuclease 5 isoform X15

    19. XM_063263741.1 → XP_063119811.1  RNA exonuclease 5 isoform X16

    20. XM_039078721.1 → XP_038934649.1  RNA exonuclease 5 isoform X8

      Conserved Domains (2) summary
      cd06145
      Location:33 → 181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:318 → 388
      RRM_SF; RNA recognition motif (RRM) superfamily

    21. XM_063263702.1 → XP_063119772.1  RNA exonuclease 5 isoform X10

      UniProtKB/TrEMBL
      A6I8N5

    22. XM_039078638.2 → XP_038934566.1  RNA exonuclease 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6L8
      Conserved Domains (2) summary
      cd06145
      Location:223 → 371
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:508 → 578
      RRM_SF; RNA recognition motif (RRM) superfamily

    23. XM_039078745.2 → XP_038934673.1  RNA exonuclease 5 isoform X13

      Conserved Domains (1) summary
      cl17169
      Location:105 → 175
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_010052978.1 RNA Sequence

    2. XR_010052985.1 RNA Sequence

    3. XR_010052980.1 RNA Sequence

    4. XR_010052979.1 RNA Sequence

    5. XR_010052983.1 RNA Sequence

    6. XR_010052981.1 RNA Sequence

    7. XR_005486561.2 RNA Sequence

    8. XR_010052982.1 RNA Sequence

    9. XR_010052987.1 RNA Sequence

    10. XR_005486573.2 RNA Sequence

    11. XR_010052991.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5R7.1 GenPept UniProtKB/Swiss-Prot:A1A5R7

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