Dhx15 DEAH-box helicase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhx15provided by MGI
Official Full Name: DEAH-box helicase 15provided by MGI
Primary source: MGI:MGI:1099786
See related: Ensembl:ENSMUSG00000029169 AllianceGenome:MGI:1099786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DBP1; HRH2; DEAH9; Ddx15; mDEAH9
Summary: Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in antiviral innate immune response and defense response to bacterium. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Is expressed in several structures, including aorta; forelimb bud; future brain; liver; and spleen. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 55.8), CNS E14 (RPKM 38.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 27.51 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (52307545..52347888, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (52150203..52190546, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
Title: Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.
Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
Title: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
Title: The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.
DHX15 is required to control RNA virus-induced intestinal inflammation.
Title: DHX15 is required to control RNA virus-induced intestinal inflammation.
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
Title: The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice.
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
Title: The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
ceria nanoparticles significantly promoted endochondral ossification-based bone regeneration by ensuring sufficient hypertrophic differentiation via the activation of the RNA helicase, DEAH (Asp-Glu-Ala-His) box helicase 15, and its downstream target, p38 MAPK.
Title: Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation.
These data demonstrate that Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes, and this effect is especially important in the intestinal tract.
Title: Nlrp6 regulates intestinal antiviral innate immunity.
DHX15, a DEXDc helicase family member, plays an important role in sensing RNA and RNA viruses in bone marrow dendritic cells.
Title: DHX15 senses double-stranded RNA in myeloid dendritic cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U12-type spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
part_of U2-type post-mRNA release spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of U2-type post-mRNA release spliceosomal complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX15

Names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A); DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

NP_001036085.1

EC 3.6.4.13

NP_031865.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042620.2 → NP_001036085.1 ATP-dependent RNA helicase DHX15 isoform 1

See identical proteins and their annotated locations for NP_001036085.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.

Source sequence(s)

AK043111, AK149869, BY285872

Consensus CDS

CCDS80280.1

UniProtKB/TrEMBL

Q3UDX4, Q497W9

Related

ENSMUSP00000143069.2, ENSMUST00000199321.5

Conserved Domains (5) summary

smart00490
Location:382 → 475

HELICc; helicase superfamily c-terminal domain

smart00487
Location:149 → 322

DEXDc; DEAD-like helicases superfamily

smart00847
Location:545 → 628

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:154 → 295

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:662 → 701

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
NM_007839.3 → NP_031865.2 ATP-dependent RNA helicase DHX15 isoform 2

See identical proteins and their annotated locations for NP_031865.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Source sequence(s)

AK145983, AK149869, BP767627, BY285872

Consensus CDS

CCDS39085.1

UniProtKB/Swiss-Prot

O35286, Q99L91

UniProtKB/TrEMBL

Q3TFE5, Q3UKJ6

Related

ENSMUSP00000031061.8, ENSMUST00000031061.12

Conserved Domains (1) summary

COG1643
Location:124 → 763

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

NR_104311.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK145983, AK168835, AK169174, BP767627, BY285872