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    Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsd3b7provided by RGD
    Official Full Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by RGD
    Primary source
    RGD:628727
    See related
    EnsemblRapid:ENSRNOG00000019080 AllianceGenome:RGD:628727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cca2
    Summary
    Enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity. Involved in cholesterol catabolic process; liver regeneration; and regulation of cell growth. Predicted to be located in lipid droplet. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1 and intrahepatic cholestasis. Orthologous to human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 642.2), Adrenal (RPKM 146.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsd3b7 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191842688..191845919)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182412216..182415447)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199248084..199251745)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A, histone lysine methyltransferase Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC134483916 Neighboring gene syntaxin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel cDNA whose corresponding mRNA is accumulated in growth-arrested confluent but not in growing sub-confluent rat 3Y1 cells. Hayashi Y, et al. Biochim Biophys Acta, 1997 May 30. PMID 9199244
    2. Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Maeda Y, et al. Ann Clin Lab Sci, 2005 Summer. PMID 16081591
    3. Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. Cheng JB, et al. J Clin Endocrinol Metab, 2003 Apr. PMID 12679481
    4. The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. Schwarz M, et al. J Clin Invest, 2000 Nov. PMID 11067870, Free PMC Article
    5. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Yi T, et al. Immunity, 2012 Sep 21. PMID 22999953, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that the mechanisms of regulation of these bile acid metabolizing enzymes are significantly different during liver regeneration
      Title: Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in B cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in bile acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3 beta-hydroxysteroid dehydrogenase type 7
    Names
    3 beta-hydroxysteroid dehydrogenase type VII
    3-beta-HSD VII
    3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
    c(27) 3-beta-HSD
    cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
    confluent 3Y1 cell-associated 2
    NP_001385604.1
    NP_647545.2
    XP_038955467.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398675.1 → NP_001385604.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35048
      UniProtKB/TrEMBL
      A0A8I6APT0, A6I9U5
      Related
      ENSRNOP00000102339.1, ENSRNOT00000162091.1
      Conserved Domains (1) summary
      cl21454
      Location:11 → 361
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_139329.3 → NP_647545.2  3 beta-hydroxysteroid dehydrogenase type 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35048
      UniProtKB/TrEMBL
      A6I9U6
      Related
      ENSRNOP00000091092.2, ENSRNOT00000097840.2
      Conserved Domains (1) summary
      cl21454
      Location:11 → 330
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191842688..191845919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099539.2 → XP_038955467.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform X1

      UniProtKB/Swiss-Prot
      O35048
      Conserved Domains (1) summary
      cl21454
      Location:11 → 317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35048.1 GenPept UniProtKB/Swiss-Prot:O35048

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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