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    Dmac2l distal membrane arm assembly component 2 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmac2lprovided by RGD
    Official Full Name
    distal membrane arm assembly component 2 likeprovided by RGD
    Primary source
    RGD:1359208
    See related
    EnsemblRapid:ENSRNOG00000004893 AllianceGenome:RGD:1359208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5s
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in ATP biosynthetic process and proton transmembrane transport. Predicted to be located in mitochondrion. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Predicted to be active in cytoplasm. Orthologous to human DMAC2L (distal membrane arm assembly component 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 109.1), Heart (RPKM 94.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmac2l in Genome Data Viewer
    Location:
    6q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93941605..93959932)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88205580..88223934)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92057782..92076022)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized LOC102548655 Neighboring gene cyclin dependent kinase like 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Sanadi DR, et al. Proc Natl Acad Sci U S A, 1984 Mar. PMID 6143319, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94488

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit s, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
    ATP synthase-coupling factor B
    Factor B
    distal membrane arm assembly complex 2 like
    distal membrane arm assembly complex 2-like protein
    mitochondrial ATP synthase regulatory component factor B
    NP_001007750.1
    XP_006240236.1
    XP_006240237.1
    XP_006240238.1
    XP_038968432.1
    XP_038968433.1
    XP_063118186.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007749.1 → NP_001007750.1  ATP synthase subunit s, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001007750.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083655
      UniProtKB/Swiss-Prot
      Q5XIM4
      UniProtKB/TrEMBL
      A6HBX3
      Related
      ENSRNOP00000006509.4, ENSRNOT00000006509.7
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93941605..93959932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240176.5 → XP_006240238.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240238.1

      UniProtKB/Swiss-Prot
      Q5XIM4
      UniProtKB/TrEMBL
      A6HBX3
      Related
      ENSRNOP00000101455.1, ENSRNOT00000132134.1
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_006240175.5 → XP_006240237.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240237.1

      UniProtKB/Swiss-Prot
      Q5XIM4
      UniProtKB/TrEMBL
      A6HBX3
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_063262116.1 → XP_063118186.1  ATP synthase subunit s, mitochondrial isoform X2

    4. XM_006240174.5 → XP_006240236.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240236.1

      UniProtKB/Swiss-Prot
      Q5XIM4
      UniProtKB/TrEMBL
      A6HBX3
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    5. XM_039112504.2 → XP_038968432.1  ATP synthase subunit s, mitochondrial isoform X3

      Conserved Domains (2) summary
      cd09293
      Location:5 → 69
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:15 → 42
      LRR_AMN1; leucine-rich repeat [structural motif]

    6. XM_039112505.2 → XP_038968433.1  ATP synthase subunit s, mitochondrial isoform X3

      Conserved Domains (2) summary
      cd09293
      Location:5 → 69
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:15 → 42
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIM4.1 GenPept UniProtKB/Swiss-Prot:Q5XIM4

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