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    Trim2 tripartite motif-containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361970, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Trim2provided by RGD
    Official Full Name
    tripartite motif-containing 2provided by RGD
    Primary source
    RGD:1310981
    See related
    EnsemblRapid:ENSRNOG00000010124 AllianceGenome:RGD:1310981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in regulation of neuron apoptotic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 375.4), Kidney (RPKM 110.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (171798654..171950193, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169500628..169652855, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (183145096..183223819, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene peflin pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene uncharacterized LOC102550635 Neighboring gene uncharacterized LOC134485931 Neighboring gene uncharacterized LOC120100858 Neighboring gene FH2 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma. Xu K, et al. J Gene Med, 2021 Nov. PMID 34291866
    2. Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M, et al. Proc Natl Acad Sci U S A, 2008 Aug 19. PMID 18687884, Free PMC Article
    3. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, et al. J Biol Chem, 2011 Jun 3. PMID 21478148, Free PMC Article
    4. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article
    5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma.
      Title: MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma.
    2. a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance.
      Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 2
    Names
    E3 ubiquitin-protein ligase TRIM2
    RING-type E3 ubiquitin transferase TRIM2
    tripartite motif protein 2
    NP_001102022.1
    XP_038958566.1
    XP_038958567.1
    XP_038958568.1
    XP_038958569.1
    XP_038958570.1
    XP_038958571.1
    XP_038958572.1
    XP_038958574.1
    XP_038958576.1
    XP_063138188.1
    XP_063138189.1
    XP_063138190.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108552.3 → NP_001102022.1  tripartite motif-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001102022.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZV62, D3ZM62
      Conserved Domains (6) summary
      smart00502
      Location:178 → 304
      BBC; B-Box C-terminal domain
      smart00557
      Location:342 → 438
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:24 → 126
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:488 → 761
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:37 → 82
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:132 → 173
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    2. NM_001430453.1 → NP_001417382.1  tripartite motif-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K2M8, A0A8I5ZV62

    3. NM_001430454.1 → NP_001417383.1  tripartite motif-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZV62

    4. NM_001430455.1 → NP_001417384.1  tripartite motif-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZV62

    5. NM_001430456.1 → NP_001417385.1  tripartite motif-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZV62

    6. NM_001430457.1 → NP_001417386.1  tripartite motif-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      D3ZQG6
      UniProtKB/TrEMBL
      A0A8I5ZV62

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      171798654..171950193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102646.2 → XP_038958574.1  tripartite motif-containing protein 2 isoform X8

      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:7 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    2. XM_063282118.1 → XP_063138188.1  tripartite motif-containing protein 2 isoform X6

      Related
      ENSRNOP00000072306.2, ENSRNOT00000085382.3

    3. XM_039102642.2 → XP_038958570.1  tripartite motif-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZV62
      Conserved Domains (6) summary
      smart00502
      Location:187 → 313
      BBC; B-Box C-terminal domain
      smart00557
      Location:351 → 447
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:33 → 135
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:497 → 774
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:46 → 91
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:141 → 182
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    4. XM_039102644.2 → XP_038958572.1  tripartite motif-containing protein 2 isoform X8

      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:7 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    5. XM_039102639.2 → XP_038958567.1  tripartite motif-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV62, A0A8I5ZY23
      Related
      ENSRNOP00000082573.2, ENSRNOT00000107931.2
      Conserved Domains (6) summary
      smart00502
      Location:222 → 348
      BBC; B-Box C-terminal domain
      smart00557
      Location:386 → 482
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:68 → 170
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:532 → 805
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:81 → 126
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:176 → 217
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    6. XM_039102638.2 → XP_038958566.1  tripartite motif-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV62
      Conserved Domains (6) summary
      smart00502
      Location:222 → 348
      BBC; B-Box C-terminal domain
      smart00557
      Location:386 → 482
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:68 → 170
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:532 → 809
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:81 → 126
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:176 → 217
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    7. XM_063282120.1 → XP_063138190.1  tripartite motif-containing protein 2 isoform X9

    8. XM_039102643.2 → XP_038958571.1  tripartite motif-containing protein 2 isoform X7

      Related
      ENSRNOP00000060362.4, ENSRNOT00000067618.4
      Conserved Domains (6) summary
      smart00502
      Location:178 → 304
      BBC; B-Box C-terminal domain
      smart00557
      Location:342 → 438
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:24 → 126
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:488 → 765
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:37 → 82
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:132 → 173
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    9. XM_039102648.2 → XP_038958576.1  tripartite motif-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZV62
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:7 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    10. XM_063282119.1 → XP_063138189.1  tripartite motif-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZV62

    11. XM_039102640.2 → XP_038958568.1  tripartite motif-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZV62
      Conserved Domains (6) summary
      smart00502
      Location:222 → 348
      BBC; B-Box C-terminal domain
      smart00557
      Location:386 → 482
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:68 → 170
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:532 → 712
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:81 → 126
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:176 → 217
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    12. XM_039102641.2 → XP_038958569.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZV62
      Conserved Domains (7) summary
      smart00502
      Location:222 → 348
      BBC; B-Box C-terminal domain
      smart00557
      Location:386 → 482
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:68 → 170
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:532 → 708
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd00162
      Location:84 → 124
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19824
      Location:176 → 217
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
      cl17238
      Location:81 → 126
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZQG6.2 GenPept UniProtKB/Swiss-Prot:D3ZQG6

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