Tlcd3b TLC domain containing 3B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tlcd3bprovided by RGD
Official Full Name: TLC domain containing 3Bprovided by RGD
Primary source: RGD:1308215
See related: EnsemblRapid:ENSRNOG00000019914 AllianceGenome:RGD:1308215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam57b; RGD1308215
Summary: Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process and lipid homeostasis. Predicted to act upstream of or within negative regulation of fat cell differentiation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cone-rod dystrophy 22. Orthologous to human TLCD3B (TLC domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 29.1), Adrenal (RPKM 23.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190851582..190870278)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181421104..181439744)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198252208..198265840)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

UniSTS:235782 (e-PCR)
- UniSTS:235782

AI413816 (e-PCR)
- UniSTS:159690

RH129916 (e-PCR)
- UniSTS:213204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide synthase

Names: TLC domain ceramide synthase 3B; family with sequence similarity 57, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.