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    Tlcd3b TLC domain containing 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293493, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tlcd3bprovided by RGD
    Official Full Name
    TLC domain containing 3Bprovided by RGD
    Primary source
    RGD:1308215
    See related
    EnsemblRapid:ENSRNOG00000019914 AllianceGenome:RGD:1308215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam57b; RGD1308215
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process and lipid homeostasis. Predicted to act upstream of or within negative regulation of fat cell differentiation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cone-rod dystrophy 22. Orthologous to human TLCD3B (TLC domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 29.1), Adrenal (RPKM 23.4) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tlcd3b in Genome Data Viewer
    Location:
    1q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190851582..190870278)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181421104..181439744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198252208..198265840)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691235 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483857 Neighboring gene similar to human chromosome 16 open reading frame 92 Neighboring gene double C2 domain alpha Neighboring gene INO80 complex subunit E

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ceramide synthase
    Names
    TLC domain ceramide synthase 3B
    family with sequence similarity 57, member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106296.2NP_001099766.2  ceramide synthase

      See identical proteins and their annotated locations for NP_001099766.2

      Status: PROVISIONAL

      Source sequence(s)
      BC161920
      UniProtKB/TrEMBL
      A6I9F8, B1WBX0, F7FL67
      Related
      ENSRNOP00000111506.1, ENSRNOT00000125667.1
      Conserved Domains (1) summary
      smart00724
      Location:40261
      TLC; TRAM, LAG1 and CLN8 homology domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190851582..190870278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230237.5XP_006230299.1  ceramide synthase isoform X1

      See identical proteins and their annotated locations for XP_006230299.1

      UniProtKB/TrEMBL
      A0A8I5ZTW5, A6I9F5, A6I9F8
      Conserved Domains (1) summary
      smart00724
      Location:40261
      TLC; TRAM, LAG1 and CLN8 homology domains
    2. XM_063286141.1XP_063142211.1  ceramide synthase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTW5, A6I9F5, A6I9F8
      Related
      ENSRNOP00000080837.1, ENSRNOT00000107014.2
    3. XM_039107392.2XP_038963320.1  ceramide synthase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTW5, A6I9F5, A6I9F8
      Related
      ENSRNOP00000026955.5, ENSRNOT00000026955.7
      Conserved Domains (1) summary
      smart00724
      Location:40261
      TLC; TRAM, LAG1 and CLN8 homology domains