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    Zfp57 zinc finger protein 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp57provided by RGD
    Official Full Name
    zinc finger protein 57provided by RGD
    Primary source
    RGD:1302981
    See related
    EnsemblRapid:ENSRNOG00000022730 AllianceGenome:RGD:1302981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and double-stranded methylated DNA binding activity. Predicted to be involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation. Predicted to act upstream of or within epigenetic programming in the zygotic pronuclei; genomic imprinting; and negative regulation of transcription by RNA polymerase II. Predicted to be located in heterochromatin and nucleus. Orthologous to human ZFP57 (ZFP57 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 62.5), Lung (RPKM 40.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp57 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1526565..1546480, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1521323..1534884, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2014177..2020488, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily H member 2 Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene RT1 class Ib, locus M5 Neighboring gene RT1 class Ib, locus M4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Mackay DJ, et al. Nat Genet, 2008 Aug. PMID 18622393
    2. A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. Okazaki S, et al. J Biol Chem, 1994 Mar 4. PMID 8120052
    3. ZNF445 is a primary regulator of genomic imprinting. Takahashi N, et al. Genes Dev, 2019 Jan 1. PMID 30602440, Free PMC Article
    4. Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system. Alonso MB, et al. J Biol Chem, 2004 Jun 11. PMID 15070898
    5. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Li X, et al. Dev Cell, 2008 Oct. PMID 18854139, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156546

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autosome genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autosome genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autosome genomic imprinting ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in epigenetic programing of female pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 57
    Names
    zfp-57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213565.4 → NP_998730.2  zinc finger protein 57

      See identical proteins and their annotated locations for NP_998730.2

      Status: VALIDATED

      Source sequence(s)
      BC127468, CA511208
      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64
      Related
      ENSRNOP00000011704.5, ENSRNOT00000011704.10
      Conserved Domains (3) summary
      smart00349
      Location:17 → 70
      KRAB; krueppel associated box
      sd00017
      Location:92 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169 → 190
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      1526565..1546480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279194.1 → XP_063135264.1  zinc finger protein 57 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64

    2. XM_063279195.1 → XP_063135265.1  zinc finger protein 57 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64

    3. XM_063279196.1 → XP_063135266.1  zinc finger protein 57 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64

    4. XM_039098787.2 → XP_038954715.1  zinc finger protein 57 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64
      Conserved Domains (3) summary
      smart00349
      Location:17 → 70
      KRAB; krueppel associated box
      sd00017
      Location:92 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169 → 190
      zf-C2H2; Zinc finger, C2H2 type

    5. XM_063279197.1 → XP_063135267.1  zinc finger protein 57 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK3, Q6MFY0
      UniProtKB/TrEMBL
      A0A8I6AQF9, A6KR64
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JPK3.1 GenPept UniProtKB/Swiss-Prot:A0JPK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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