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    Ctnna3 catenin alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361839, updated on 27-Dec-2024

    Summary

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    Symbol
    Ctnna3provided by RGD
    Full Name
    catenin alpha 3provided by RGD
    Primary source
    RGD:1562230
    See related
    EnsemblRapid:ENSRNOG00000000373 AllianceGenome:RGD:1562230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Catna3; RGD1559455; RGD1562230; AABR07044900.1
    Summary
    Predicted to enable actin filament binding activity and beta-catenin binding activity. Predicted to be involved in cell migration and regulation of heart contraction. Predicted to be located in lamellipodium. Predicted to be active in adherens junction and fascia adherens. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 59.4), Muscle (RPKM 29.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctnna3 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (23613016..25198699, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (23614469..25200026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (25063124..26640428, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102552717 Neighboring gene ubiquitin-conjugating enzyme E2 S-like Neighboring gene uncharacterized LOC134483906 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene eukaryotic translation initiation factor 3, subunit G, pseudogene 1 Neighboring gene transmembrane protein 167B, pseudogene 1 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 30 Neighboring gene ubiquitin conjugating enzyme E2 V2, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon AGC) 21 Neighboring gene transfer RNA serine (anticodon UGA) 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. Janssens B, et al. J Cell Sci, 2001 Sep. PMID 11590244
    2. Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. van Hengel J, et al. Eur Heart J, 2013 Jan. PMID 23136403
    3. A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. Goossens S, et al. J Cell Sci, 2007 Jun 15. PMID 17535849
    4. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. Gavard J, et al. J Cell Sci, 2004 Jan 15. PMID 14657280
    5. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Daneman R, et al. Proc Natl Acad Sci U S A, 2009 Jan 13. PMID 19129494, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188744

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fascia adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    catenin alpha-3
    Names
    catenin (cadherin associated protein), alpha 3
    rCG61001-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426985.1 → NP_001413914.1  catenin alpha-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JKY1
      Related
      ENSRNOP00000078455.2, ENSRNOT00000099024.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      23613016..25198699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099277.2 → XP_038955205.1  catenin alpha-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX81, A6JKY1
      Related
      ENSRNOP00000070169.2, ENSRNOT00000084660.3
      Conserved Domains (1) summary
      pfam01044
      Location:102 → 875
      Vinculin; Vinculin family

    2. XM_008772944.4 → XP_008771166.3  catenin alpha-3 isoform X2

      UniProtKB/TrEMBL
      A6JKY1
      Conserved Domains (1) summary
      pfam01044
      Location:83 → 856
      Vinculin; Vinculin family

    3. XM_017601852.3 → XP_017457341.2  catenin alpha-3 isoform X3

      UniProtKB/TrEMBL
      F1M4I1
      Conserved Domains (1) summary
      pfam01044
      Location:10 → 589
      Vinculin; Vinculin family

    4. XM_039099279.2 → XP_038955207.1  catenin alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKV7
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 510
      Vinculin; Vinculin family

    5. XM_008772942.4 → XP_008771164.3  catenin alpha-3 isoform X5

      Conserved Domains (1) summary
      pfam01044
      Location:1 → 491
      Vinculin; Vinculin family

    6. XM_039099280.2 → XP_038955208.1  catenin alpha-3 isoform X6

      Conserved Domains (1) summary
      pfam01044
      Location:102 → 449
      Vinculin; Vinculin family

    7. XM_063279292.1 → XP_063135362.1  catenin alpha-3 isoform X9

    8. XM_063279290.1 → XP_063135360.1  catenin alpha-3 isoform X7

    9. XM_063279291.1 → XP_063135361.1  catenin alpha-3 isoform X8

    10. XM_063279293.1 → XP_063135363.1  catenin alpha-3 isoform X10

    RNA

    1. XR_010060727.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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