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    Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300732, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pstpip1provided by RGD
    Official Full Name
    proline-serine-threonine phosphatase-interacting protein 1provided by RGD
    Primary source
    RGD:1307557
    See related
    EnsemblRapid:ENSRNOG00000016413 AllianceGenome:RGD:1307557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; identical protein binding activity; and protein phosphatase binding activity. Predicted to be located in actin cytoskeleton; cleavage furrow; and cytosol. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 150.4), Spleen (RPKM 85.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pstpip1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (65395328..65434616)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (56499287..56538593)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60760040..60799364)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351848 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene tetraspanin 3 Neighboring gene ribosomal protein L17, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Yu JW, et al. Mol Cell, 2007 Oct 26. PMID 17964261, Free PMC Article
    2. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. Spencer S, et al. J Cell Biol, 1997 Aug 25. PMID 9265651, Free PMC Article
    3. Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL. Baum W, et al. J Biol Chem, 2005 Dec 2. PMID 16204241
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
      Title: Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in actomyosin contractile ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proline-serine-threonine phosphatase-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106824.2 → NP_001100294.2  proline-serine-threonine phosphatase-interacting protein 1

      See identical proteins and their annotated locations for NP_001100294.2

      Status: PROVISIONAL

      Source sequence(s)
      BC158859
      UniProtKB/TrEMBL
      B0BNK4
      Related
      ENSRNOP00000079186.1, ENSRNOT00000110505.2
      Conserved Domains (2) summary
      cd11824
      Location:363 → 415
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:16 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      65395328..65434616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243113.5 → XP_006243175.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X1

      Conserved Domains (2) summary
      cd11824
      Location:360 → 412
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:16 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_039081083.2 → XP_038937011.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X3

      Conserved Domains (2) summary
      cd11824
      Location:329 → 381
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:1 → 223
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_017595555.3 → XP_017451044.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      F7FFM6
      Related
      ENSRNOP00000061918.2, ENSRNOT00000063930.4

    4. XM_039081084.2 → XP_038937012.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X4

      Conserved Domains (2) summary
      cd11824
      Location:241 → 293
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:1 → 135
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_005487766.2 RNA Sequence

    2. XR_005487765.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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