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    Srp72 signal recognition particle 72 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498351, updated on 27-Dec-2024

    Summary

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    Symbol
    Srp72provided by RGD
    Full Name
    signal recognition particle 72provided by RGD
    Primary source
    RGD:1564787
    See related
    EnsemblRapid:ENSRNOG00000002100 AllianceGenome:RGD:1564787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 7S RNA binding activity; TPR domain binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 143.9), Kidney (RPKM 143.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srp72 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31522424..31549978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31168175..31195717, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33447583..33453788, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 like Neighboring gene uncharacterized LOC134481837 Neighboring gene uncharacterized LOC120096735 Neighboring gene ARF like GTPase 9 Neighboring gene uncharacterized LOC120096737 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia. Kirwan M, et al. Am J Hum Genet, 2012 May 4. PMID 22541560, Free PMC Article
    2. Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. Menichelli E, et al. J Mol Biol, 2007 Mar 16. PMID 17254600
    3. Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Becker MM, et al. Nucleic Acids Res, 2017 Jan 9. PMID 27899666, Free PMC Article
    4. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Yoshida M, et al. Mol Pharmacol, 2008 Mar. PMID 18089836
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle subunit SRP72
    Names
    signal recognition particle 72 kDa protein
    signal recognition particle 72 kDa protein-like
    signal recognition particle 72kDa
    signal recognition particle subunit SRP72-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170601.1 → NP_001164072.1  signal recognition particle subunit SRP72

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AW91, F7FFH0
      Related
      ENSRNOP00000082438.1, ENSRNOT00000104763.2
      Conserved Domains (7) summary
      sd00006
      Location:176 → 204
      TPR; TPR repeat [structural motif]
      pfam08492
      Location:531 → 584
      SRP72; SRP72 RNA-binding domain
      pfam12895
      Location:57 → 134
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:175 → 255
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:351 → 414
      TPR_19; Tetratricopeptide repeat
      pfam17004
      Location:36 → 157
      SRP_TPR_like; Putative TPR-like repeat
      cl23899
      Location:344 → 523
      Spore_YpjB; Sporulation protein YpjB (SpoYpjB)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31522424..31549978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092285.2 → XP_038948213.1  signal recognition particle subunit SRP72 isoform X1

      UniProtKB/TrEMBL
      D4A7R0, F7FFH0
      Related
      ENSRNOP00000002862.5, ENSRNOT00000002862.8
      Conserved Domains (4) summary
      TIGR02917
      Location:25 → 460
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:176 → 204
      TPR; TPR repeat [structural motif]
      pfam17004
      Location:36 → 157
      SRP_TPR_like; Putative TPR-like repeat
      pfam08492
      Location:489 → 541
      SRP72; SRP72 RNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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