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    Tmem134 transmembrane protein 134 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem134provided by RGD
    Official Full Name
    transmembrane protein 134provided by RGD
    Primary source
    RGD:1305824
    See related
    EnsemblRapid:ENSRNOG00000022153 AllianceGenome:RGD:1305824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305824
    Summary
    Predicted to be located in cytosol and perinuclear region of cytoplasm. Orthologous to human TMEM134 (transmembrane protein 134). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 193.8), Muscle (RPKM 180.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem134 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210848761..210857735)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201419225..201424778)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219374005..219383365)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152 Neighboring gene ribosomal protein L35A, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway. Tian Y, et al. Virus Res, 2017 Jan 15. PMID 27899274
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078647.1 → NP_001072115.1  transmembrane protein 134 isoform a

      See identical proteins and their annotated locations for NP_001072115.1

      Status: VALIDATED

      Source sequence(s)
      AW434905, BP495609, BQ190138
      UniProtKB/TrEMBL
      A0A8I6A5Q3, A6HYT7, D3ZF56
      Related
      ENSRNOP00000031381.5, ENSRNOT00000030340.8
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 193
      DUF872; Eukaryotic protein of unknown function (DUF872)

    2. NM_001078648.1 → NP_001072116.1  transmembrane protein 134 isoform b

      See identical proteins and their annotated locations for NP_001072116.1

      Status: VALIDATED

      Source sequence(s)
      BI278839, BP495609
      UniProtKB/TrEMBL
      A0A8I6A5Q3, A6HYT8, D4A3S9
      Related
      ENSRNOP00000035615.2, ENSRNOT00000030324.4
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 178
      DUF872; Eukaryotic protein of unknown function (DUF872)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210848761..210857735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268167.1 → XP_063124237.1  transmembrane protein 134 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5Q3
      Related
      ENSRNOP00000109775.1, ENSRNOT00000158520.1

    2. XM_063268169.1 → XP_063124239.1  transmembrane protein 134 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A5Q3

    3. XM_039083754.2 → XP_038939682.1  transmembrane protein 134 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5Q3
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 168
      DUF872; Eukaryotic protein of unknown function (DUF872)

    4. XM_039083761.2 → XP_038939689.1  transmembrane protein 134 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A5Q3
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 153
      DUF872; Eukaryotic protein of unknown function (DUF872)

    5. XM_039083743.2 → XP_038939671.1  transmembrane protein 134 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5Q3, A6HYT9
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 184
      DUF872; Eukaryotic protein of unknown function (DUF872)

    6. XM_063268164.1 → XP_063124234.1  transmembrane protein 134 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5Q3

    7. XM_063268165.1 → XP_063124235.1  transmembrane protein 134 isoform X4

    8. XM_063268170.1 → XP_063124240.1  transmembrane protein 134 isoform X9

    9. XM_039083773.2 → XP_038939701.1  transmembrane protein 134 isoform X10

    10. XM_039083764.2 → XP_038939692.1  transmembrane protein 134 isoform X8

      Conserved Domains (1) summary
      pfam05915
      Location:5 → 109
      DUF872; Eukaryotic protein of unknown function (DUF872)
    Nucleotide Protein Strain
    Heading Accession and Version

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