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    Cmc1 C-x(9)-C motif containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cmc1provided by RGD
    Official Full Name
    C-x(9)-C motif containing 1provided by RGD
    Primary source
    RGD:1305283
    See related
    EnsemblRapid:ENSRNOG00000010149 AllianceGenome:RGD:1305283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305283
    Summary
    Predicted to be active in mitochondrion. Orthologous to human CMC1 (C-X9-C motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 76.9), Liver (RPKM 62.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmc1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (126677560..126778403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (117798036..117900458, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (126437345..126495347, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094353 Neighboring gene zinc finger CW-type and PWWP domain containing 2 Neighboring gene 5-azacytidine induced 2 Neighboring gene uncharacterized LOC120094354 Neighboring gene uncharacterized LOC108351794 Neighboring gene uncharacterized LOC102547938

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Fischer M, et al. Mol Biol Cell, 2013 Jul. PMID 23676665, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COX assembly mitochondrial protein homolog
    Names
    COX assembly mitochondrial protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135259.2 → NP_001128731.1  COX assembly mitochondrial protein homolog isoform 2

      See identical proteins and their annotated locations for NP_001128731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' CDS and 3' UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3T9
      Conserved Domains (1) summary
      pfam08583
      Location:19 → 66
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    2. NM_001199225.1 → NP_001186154.1  COX assembly mitochondrial protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001186154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3T7
      Conserved Domains (1) summary
      pfam08583
      Location:19 → 87
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      126677560..126778403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081810.2 → XP_038937738.1  COX assembly mitochondrial protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6B5X8
      Conserved Domains (1) summary
      pfam08583
      Location:64 → 132
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    2. XM_039081809.2 → XP_038937737.1  COX assembly mitochondrial protein homolog isoform X1

      Related
      ENSRNOP00000097555.2, ENSRNOT00000109221.2
      Conserved Domains (1) summary
      pfam08583
      Location:64 → 155
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    3. XM_006244034.5 → XP_006244096.1  COX assembly mitochondrial protein homolog isoform X3

      UniProtKB/TrEMBL
      D3ZTN2
      Conserved Domains (1) summary
      pfam08583
      Location:19 → 110
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    4. XM_063265846.1 → XP_063121916.1  COX assembly mitochondrial protein homolog isoform X5

    5. XM_063265845.1 → XP_063121915.1  COX assembly mitochondrial protein homolog isoform X4

      Related
      ENSRNOP00000106349.1, ENSRNOT00000129391.1

    6. XM_063265847.1 → XP_063121917.1  COX assembly mitochondrial protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6APA1, A6I3T8
    Nucleotide Protein Strain
    Heading Accession and Version

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