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    Ndrg3 NDRG family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndrg3provided by RGD
    Official Full Name
    NDRG family member 3provided by RGD
    Primary source
    RGD:1359424
    See related
    EnsemblRapid:ENSRNOG00000036813 AllianceGenome:RGD:1359424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in decidualization and signal transduction. Predicted to be active in cytoplasm. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Ndrg3 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166007556..166070981, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145587505..145650896, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152972055..153099089, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein NDRG3-like Neighboring gene protein NDRG3-like Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene microtubule crosslinking factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3. Yang Z, et al. Mol Cell Biochem, 2021 Feb. PMID 33247804
    2. Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3. Yao Y, et al. Neurochem Res, 2017 Feb. PMID 27812761
    3. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Qu X, et al. Mol Cell Biochem, 2002 Jan. PMID 11936845
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3.
      Title: MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3.
    2. In the hypoxic response of cerebral ischemia, NDRG3 expression was found to be regulated by let-7f microRNA.
      Title: Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in decidualization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG3
    Names
    N-myc downstream regulated 3
    N-myc downstream regulated gene 3
    N-myc downstream regulated gene 3-like
    N-myc downstream-regulated gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013923.2 → NP_001013945.1  protein NDRG3

      See identical proteins and their annotated locations for NP_001013945.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AYR2
      UniProtKB/TrEMBL
      A0A8I6ASR6
      Related
      ENSRNOP00000086721.1, ENSRNOT00000109829.2
      Conserved Domains (2) summary
      COG0596
      Location:39 → 312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166007556..166070981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283384.1 → XP_063139454.1  protein NDRG3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6ASR6

    2. XM_039104620.2 → XP_038960548.1  protein NDRG3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ASR6
      Conserved Domains (1) summary
      pfam03096
      Location:20 → 305
      Ndr; Ndr family

    3. XM_063283380.1 → XP_063139450.1  protein NDRG3 isoform X3

    4. XM_063283377.1 → XP_063139447.1  protein NDRG3 isoform X1

    5. XM_039104617.2 → XP_038960545.1  protein NDRG3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ASR6, D4ACZ5
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    6. XM_063283382.1 → XP_063139452.1  protein NDRG3 isoform X6

      UniProtKB/Swiss-Prot
      Q6AYR2
      UniProtKB/TrEMBL
      A0A8I6ASR6

    7. XM_063283381.1 → XP_063139451.1  protein NDRG3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ASR6, D4ACZ5
      Related
      ENSRNOP00000052106.4, ENSRNOT00000055232.5

    8. XM_063283378.1 → XP_063139448.1  protein NDRG3 isoform X1

    9. XM_063283379.1 → XP_063139449.1  protein NDRG3 isoform X2

    10. XM_063283385.1 → XP_063139455.1  protein NDRG3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6ASR6

    11. XM_063283383.1 → XP_063139453.1  protein NDRG3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ASR6

    12. XM_039104623.2 → XP_038960551.1  protein NDRG3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ASR6
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    RNA

    1. XR_010064592.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYR2.1 GenPept UniProtKB/Swiss-Prot:Q6AYR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials