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    Adgrf5 adhesion G protein-coupled receptor F5 [ Mus musculus (house mouse) ]

    Gene ID: 224792, updated on 4-Jan-2025

    Summary

    Official Symbol
    Adgrf5provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F5provided by MGI
    Primary source
    MGI:MGI:2182928
    See related
    Ensembl:ENSMUSG00000056492 AllianceGenome:MGI:2182928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr116; mKIAA0758; 9330185D23; 8430401C09Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in surfactant homeostasis. Acts upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in lung adult (RPKM 73.9), subcutaneous fat pad adult (RPKM 17.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Adgrf5 in Genome Data Viewer
    Location:
    17 B3; 17 19.73 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43671225..43770448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43360329..43459557)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54007 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43402088-43402388 Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene STARR-seq mESC enhancer starr_42590 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha Neighboring gene ankyrin repeat domain 66

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables molecular_function  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in cell surface receptor signaling pathway  
    involved_in energy reserve metabolic process  
    acts_upstream_of_or_within energy reserve metabolic process PubMed 
    acts_upstream_of_or_within erythrocyte development PubMed 
    involved_in fat cell differentiation  
    acts_upstream_of_or_within fat cell differentiation PubMed 
    acts_upstream_of_or_within glomerular filtration PubMed 
    acts_upstream_of_or_within glucose homeostasis PubMed 
    acts_upstream_of macrophage activation PubMed 
    acts_upstream_of_or_within negative regulation of macrophage activation PubMed 
    acts_upstream_of_or_within pharyngeal arch artery morphogenesis PubMed 
    acts_upstream_of phospholipid biosynthetic process PubMed 
    acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process PubMed 
    involved_in regulation of lipid metabolic process  
    acts_upstream_of_or_within regulation of lipid metabolic process PubMed 
    acts_upstream_of_or_within surfactant homeostasis PubMed 
    involved_in surfactant homeostasis PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    located_in cell surface  
    is_active_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in plasma membrane  

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor F5
    Names
    G protein coupled receptor Gpr116
    G protein-coupled receptor 116
    G-protein coupled hepta-helical receptor Ig-hepta
    Ig-Hepta
    probable G-protein coupled receptor 116

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081178.2NP_001074647.1  adhesion G protein-coupled receptor F5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001074647.1

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      Consensus CDS
      CCDS37622.1
      UniProtKB/Swiss-Prot
      G5E8Q8
      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000109229.2, ENSMUST00000113599.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:471544
      Ig_3; Immunoglobulin domain
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001357332.1NP_001344261.1  adhesion G protein-coupled receptor F5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, AW457181, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
      Conserved Domains (5) summary
      smart00410
      Location:301375
      IG_like; Immunoglobulin like
      cd14964
      Location:10321056
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam00047
      Location:495568
      ig; Immunoglobulin domain
      pfam01825
      Location:9691016
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:10301303
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001404529.1NP_001391458.1  adhesion G protein-coupled receptor F5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    4. NM_001404530.1NP_001391459.1  adhesion G protein-coupled receptor F5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    5. NM_001404536.1NP_001391465.1  adhesion G protein-coupled receptor F5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
    6. NM_001404541.1NP_001391470.1  adhesion G protein-coupled receptor F5 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    7. NM_001404546.1NP_001391475.1  adhesion G protein-coupled receptor F5 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    8. NM_001404548.1NP_001391477.1  adhesion G protein-coupled receptor F5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43671225..43770448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524128.5XP_006524191.1  adhesion G protein-coupled receptor F5 isoform X3

      See identical proteins and their annotated locations for XP_006524191.1

      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000153373.2, ENSMUST00000225962.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      cd14964
      Location:10531078
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam00047
      Location:517590
      ig; Immunoglobulin domain
      pfam01825
      Location:9911038
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:10521325
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_036160548.1XP_036016441.1  adhesion G protein-coupled receptor F5 isoform X7

      UniProtKB/Swiss-Prot
      G5E8Q8
      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000153049.2, ENSMUST00000226087.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:471544
      Ig_3; Immunoglobulin domain
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_036160547.1XP_036016440.1  adhesion G protein-coupled receptor F5 isoform X6

      Conserved Domains (5) summary
      smart00409
      Location:301375
      IG; Immunoglobulin
      pfam00047
      Location:491568
      ig; Immunoglobulin domain
      pfam01825
      Location:9691016
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10311056
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10301303
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. XM_036160550.1XP_036016443.1  adhesion G protein-coupled receptor F5 isoform X8

      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam00047
      Location:473550
      ig; Immunoglobulin domain
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. XM_036160549.1XP_036016442.1  adhesion G protein-coupled receptor F5 isoform X8

      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam00047
      Location:473550
      ig; Immunoglobulin domain
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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