lhx8a LIM homeobox 8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lhx8aprovided by ZNC
Official Full Name: LIM homeobox 8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031008-2
See related: Ensembl:ENSDARG00000002330 AllianceGenome:ZFIN:ZDB-GENE-031008-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lhx7; lhx8; cb875; fk78g12; wu:fk78g12
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; dental mesenchyme; pharyngeal arch 1; and pharynx. Orthologous to human LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (11205795..11210173)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (11422196..11426579)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in forebrain neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM/homeobox protein Lhx8a

Names: LIM homeobox 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003980.2 → NP_001003980.1 LIM/homeobox protein Lhx8a

See identical proteins and their annotated locations for NP_001003980.1

Status: PROVISIONAL

Source sequence(s)

AY664404

UniProtKB/TrEMBL

Q6BDC3

Related

ENSDARP00000028001.3, ENSDART00000019078.5

Conserved Domains (3) summary

cd09381
Location:50 → 105

LIM1_Lhx7_Lhx8; The first LIM domain of Lhx7 and Lhx8

cd09383
Location:112 → 166

LIM2_Lhx7_Lhx8; The second LIM domain of Lhx7 and Lhx8

pfam00046
Location:205 → 257

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

11205795..11210173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171154.5 → XP_005171211.1 LIM/homeobox protein Lhx8a isoform X1

UniProtKB/TrEMBL

A0A8M2BIF2

Conserved Domains (3) summary

cd09381
Location:46 → 101

LIM1_Lhx7_Lhx8; The first LIM domain of Lhx7 and Lhx8

cd09383
Location:108 → 162

LIM2_Lhx7_Lhx8; The second LIM domain of Lhx7 and Lhx8

pfam00046
Location:201 → 253

Homeobox; Homeobox domain