pdca phosducin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdcaprovided by ZNC
Official Full Name: phosducin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031023-1
See related: Ensembl:ENSDARG00000011886 AllianceGenome:ZFIN:ZDB-GENE-031023-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PDC; pdc1; pdcr
Summary: Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway and visual perception. Predicted to be located in several cellular components, including cilium; cytosol; and photoreceptor inner segment. Predicted to be active in photoreceptor outer segment. Is expressed in eye and retina. Orthologous to human PDC (phosducin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (20882954..20890429, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21224892..21232367, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosducin a

Names: PDCb1; phosducin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291500.1 → NP_001278429.1 phosducin a

See identical proteins and their annotated locations for NP_001278429.1

Status: VALIDATED

Source sequence(s)

CU570979

UniProtKB/TrEMBL

A0A8M1P6P2, F8W512

Related

ENSDARP00000123816.1, ENSDART00000149989.2

Conserved Domains (1) summary

cd02987
Location:9 → 216

Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...