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    mus81 MUS81 structure-specific endonuclease subunit [ Danio rerio (zebrafish) ]

    Gene ID: 406839, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mus81provided by ZNC
    Official Full Name
    MUS81 structure-specific endonuclease subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2923
    See related
    Ensembl:ENSDARG00000069326 AllianceGenome:ZFIN:ZDB-GENE-040426-2923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66489; zgc:91801; wu:fc26g01
    Summary
    Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in double-strand break repair via break-induced replication; mitotic intra-S DNA damage checkpoint signaling; and resolution of meiotic recombination intermediates. Predicted to act upstream of or within DNA recombination and double-strand break repair. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mus81 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19850915..19880266)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19598926..19628298)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TRIM39 Neighboring gene ovo-like zinc finger 1a Neighboring gene transmembrane protein 151B Neighboring gene si:ch211-285j22.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Formation of Different Polyploids Through Disrupting Meiotic Crossover Frequencies Based on cntd1 Knockout in Zebrafish. Ou Y, et al. Mol Biol Evol, 2024 Mar 1. PMID 38421617, Free PMC Article
    2. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
    3. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article
    4. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. Xia H, et al. Genetics, 2018 Feb. PMID 29196300, Free PMC Article
    5. Microarray gene expression profiling during the segmentation phase of zebrafish development. Linney E, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2004 Jul. PMID 15533793

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA endonuclease activity, producing 3'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables crossover junction DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Holliday junction resolvase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    crossover junction endonuclease MUS81
    Names
    MUS81 endonuclease homolog
    NP_998683.1
    XP_005172268.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213518.1 → NP_998683.1  crossover junction endonuclease MUS81

      See identical proteins and their annotated locations for NP_998683.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055679
      UniProtKB/Swiss-Prot
      Q7SXA9
      Conserved Domains (2) summary
      pfam02732
      Location:317 → 467
      ERCC4; ERCC4 domain
      cl11966
      Location:26 → 85
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      19850915..19880266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172211.5 → XP_005172268.1  crossover junction endonuclease MUS81 isoform X1

      See identical proteins and their annotated locations for XP_005172268.1

      UniProtKB/TrEMBL
      A0A2R8Q1X1, F6P1P2, Q6GML8
      Related
      ENSDARP00000091555.3, ENSDART00000100782.6
      Conserved Domains (2) summary
      pfam02732
      Location:325 → 475
      ERCC4; ERCC4 domain
      cl11966
      Location:44 → 85
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394684.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1202..30543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXA9.1 GenPept UniProtKB/Swiss-Prot:Q7SXA9

    Gene LinkOut

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