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    g2e3 G2/M-phase specific E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 368848, updated on 9-Dec-2024

    Summary

    Official Symbol
    g2e3provided by ZNC
    Official Full Name
    G2/M-phase specific E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-400
    See related
    Ensembl:ENSDARG00000001313 AllianceGenome:ZFIN:ZDB-GENE-030616-400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb726; wu:fe02a06; wu:fe24c12; si:dz234g15.1; si:busm1-234g15.1
    Summary
    Predicted to enable metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be active in nucleus. Is expressed in central nervous system; head; pectoral fin musculature; and proliferative region. Orthologous to human G2E3 (G2/M-phase specific E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See g2e3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (28798727..28811667, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (28781766..28794637, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene opsin 6, group member b Neighboring gene sec1 family domain containing 1 Neighboring gene si:dkey-28g23.3 Neighboring gene uncharacterized LOC108179771 Neighboring gene uncharacterized LOC137488039

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Clone Names

    • KIAA1333

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    G2/M phase-specific E3 ubiquitin-protein ligase
    Names
    G2/M-phase specific E3 ubiquitin ligase
    NP_001003822.1
    XP_021322796.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003822.1NP_001003822.1  G2/M phase-specific E3 ubiquitin-protein ligase

      See identical proteins and their annotated locations for NP_001003822.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596026
      UniProtKB/TrEMBL
      F6P7Y7, Q78AN7, Q8AW58
      Related
      ENSDARP00000001315.7, ENSDART00000001444.8
      Conserved Domains (3) summary
      cd15496
      Location:237290
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:20133
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl00077
      Location:433695
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      28798727..28811667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467121.2XP_021322796.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKK8
      Conserved Domains (3) summary
      cd15496
      Location:185238
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl22851
      Location:181
      PHD_SF; PHD finger superfamily
      cl27008
      Location:381643
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...