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    ptprna protein tyrosine phosphatase receptor type Na [ Danio rerio (zebrafish) ]

    Gene ID: 324790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptprnaprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type Naprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3511
    See related
    Ensembl:ENSDARG00000058646 AllianceGenome:ZFIN:ZDB-GENE-030131-3511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    IA-2; ptprn; fc43c04; wu:fc43c04
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and regulation of secretion. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in transport vesicle membrane. Predicted to be active in secretory granule and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ptprna in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (7548531..7619626)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (7570111..7641235)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198aa Neighboring gene desmin a Neighboring gene microRNA 153c Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC137496446 Neighboring gene uncharacterized LOC137496447 Neighboring gene tubulin, alpha 8 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Cukrov D, et al. Hum Mol Genet, 2018 Sep 1. PMID 29860495
    2. CRISPRz: a database of zebrafish validated sgRNAs. Varshney GK, et al. Nucleic Acids Res, 2016 Jan 4. PMID 26438539, Free PMC Article
    3. The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Cai T, et al. Diabetologia, 2001 Jan. PMID 11206415
    4. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
    5. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase receptor type Na
    Names
    protein tyrosine phosphatase, receptor type, N
    NP_001124060.2
    XP_017213141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130588.2 → NP_001124060.2  protein tyrosine phosphatase receptor type Na precursor

      Status: VALIDATED

      Source sequence(s)
      CU639452, CU861474
      UniProtKB/TrEMBL
      A0A8M1NL05, F1R8X1
      Related
      ENSDARP00000075984.4, ENSDART00000081543.5
      Conserved Domains (5) summary
      smart00194
      Location:633 → 892
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:660 → 892
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam10152
      Location:284 → 370
      DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
      pfam11548
      Location:395 → 480
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
      pfam14948
      Location:47 → 105
      RESP18; RESP18 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      7548531..7619626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357652.3 → XP_017213141.1  protein tyrosine phosphatase receptor type Na isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z8D6
    Nucleotide Protein
    Heading Accession and Version

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