utp25 UTP25 small subunit processor component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: utp25provided by ZNC
Official Full Name: UTP25 small subunit processor componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021217-2
See related: Ensembl:ENSDARG00000017696 AllianceGenome:ZFIN:ZDB-GENE-021217-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: def; diexf; fc51g08; fi05f05; chunp6870; dj434o14.5; wu:fc51g08; wu:fi05f05; dj434o14.5l
Summary: Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Involved in embryonic organ development and protein localization to nucleolus. Acts upstream of or within several processes, including digestive system development; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and protein destabilization. Located in nucleolus. Is expressed in digestive system and swim bladder. Orthologous to human UTP25 (UTP25 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (31925506..31938489, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (31795056..31808039, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sas10 is essential not only for delivering the Mpp10-Imp3-Imp4 complex to the nucleolus for assembling the SSU processome but also for fine-tuning Mpp10 turnover in the nucleolus during organogenesis.
Title: Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus.
Fibrotic scar formation in def+/- is blocked by the over-expression of Def.
Title: Haploinsufficiency of Def activates p53-dependent TGFβ signalling and causes scar formation after partial hepatectomy.
Def can mediate the degradation of p53 protein and that this process is independent of the proteasome pathway, but dependent on the activity of Calpain3, a cysteine protease.
Title: Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Def functions in a cell autonomous manner during early liver development.
Title: Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish.
def gene encodes a novel pan-endoderm-specific factor.p53 is tightly regulated by factor Def, especially during organogenesis
Title: Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi05f05.x1 (e-PCR)
- UniSTS:196677

fe02e09.y1 (e-PCR)
- UniSTS:195941

fc51g08 (e-PCR)
- UniSTS:189300

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables U3 snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U3 snoRNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleolus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: U3 small nucleolar RNA-associated protein 25 homolog

Names: digestive organ expansion factor homolog; digestive-organ expansion factor; lily liver; lly

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173273.1 → NP_775380.1 U3 small nucleolar RNA-associated protein 25 homolog

See identical proteins and their annotated locations for NP_775380.1

Status: PROVISIONAL

Source sequence(s)

AF506211

UniProtKB/Swiss-Prot

Q6PEH4, Q8JHI5

Related

ENSDARP00000011386.7, ENSDART00000026726.8

Conserved Domains (1) summary

pfam06862
Location:273 → 745

UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25