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    ash2l ash2 like, histone lysine methyltransferase complex subunit [ Danio rerio (zebrafish) ]

    Gene ID: 558193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ash2lprovided by ZNC
    Official Full Name
    ash2 like, histone lysine methyltransferase complex subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-494
    See related
    Ensembl:ENSDARG00000060392 AllianceGenome:ZFIN:ZDB-GENE-030131-494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb34c06; fe38b04; fi20h02; wu:fb34c06; wu:fe38b04; wu:fi20h02; zgc:171444
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ash2l in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2758825..2788702, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2731654..2761549, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene mesoderm induction early response 1, family member 3 a Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene posterior neuron-specific homeobox Neighboring gene AE binding protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. Gagnon JA, et al. PLoS One, 2014. PMID 24873830, Free PMC Article
    2. PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Ma Z, et al. Nature, 2019 Apr. PMID 30944473
    3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    set1/Ash2 histone methyltransferase complex subunit ASH2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110105.2 → NP_001103575.2  set1/Ash2 histone methyltransferase complex subunit ASH2

      Status: VALIDATED

      Source sequence(s)
      CT027796, CT627023, CT679794, CT679795, CT698001
      UniProtKB/TrEMBL
      A0A8M1NG69, F1RAW8
      Related
      ENSDARP00000079466.4, ENSDART00000085031.6
      Conserved Domains (2) summary
      cd15583
      Location:58 → 103
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:354 → 545
      SPRY_Ash2; SPRY domain in Ash2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      2758825..2788702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155525.5 → XP_005155582.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2E1
      Conserved Domains (2) summary
      cd15583
      Location:58 → 103
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:348 → 539
      SPRY_Ash2; SPRY domain in Ash2
    Nucleotide Protein Strain
    Heading Accession and Version

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