adka adenosine kinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adkaprovided by ZNC
Official Full Name: adenosine kinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030425-3
See related: Ensembl:ENSDARG00000039429 AllianceGenome:ZFIN:ZDB-GENE-030425-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adk; cb163; wu:fb39g06; wu:fb57c05; wu:fc10c08; wu:fc41g07; wu:fi37c12
Summary: Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to act upstream of or within phosphorylation and purine ribonucleoside salvage. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and periderm. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (24918594..25199279, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (24788144..25068829, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW171095 (e-PCR)
- UniSTS:205861

fb57c05.x1 (e-PCR)
- UniSTS:190761

fb57c05 (e-PCR)
- UniSTS:187180

fb21h05.x1 (e-PCR)
- UniSTS:203054

G46319 (e-PCR)
- UniSTS:107121

fc10c08.x1 (e-PCR)
- UniSTS:192434

fc10c08.x1 (e-PCR)
- UniSTS:192435

fc41g07.x1 (e-PCR)
- UniSTS:188153

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine kinase

NP_001259013.1

EC 2.7.1.20

NP_997956.1

EC 2.7.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001272084.1 → NP_001259013.1 adenosine kinase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AL929334, CR788251

UniProtKB/TrEMBL

A0A0R4IYX1, A0A8M1NZA9

Related

ENSDARP00000140675.1, ENSDART00000159585.2

Conserved Domains (2) summary

PTZ00247
Location:9 → 344

PTZ00247; adenosine kinase; Provisional

cl00192
Location:12 → 344

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_212791.2 → NP_997956.1 adenosine kinase isoform 1

See identical proteins and their annotated locations for NP_997956.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AL929334, CR788251

UniProtKB/TrEMBL

A0A8M1PHW6, Q6P3J9

Related

ENSDARP00000057604.5, ENSDART00000057605.7

Conserved Domains (2) summary

PTZ00247
Location:23 → 358

PTZ00247; adenosine kinase; Provisional

cl00192
Location:26 → 358

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...