ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ezh2provided by ZNC
Official Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041111-259
See related: Ensembl:ENSDARG00000010571 AllianceGenome:ZFIN:ZDB-GENE-041111-259
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eya2; im:7149338; zgc:136376; zgc:152758
Summary: Enables histone H3K27 methyltransferase activity and transcription coactivator activity. Involved in positive regulation of circadian rhythm and positive regulation of hemopoiesis. Acts upstream of or within several processes, including digestive tract development; fin regeneration; and tissue homeostasis. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; digestive system; eye; gonad; and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (17345535..17364454)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (17201116..17220035)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EZH2 specifically regulates ISL1 during embryonic urinary tract formation.
Title: EZH2 specifically regulates ISL1 during embryonic urinary tract formation.
Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2.
Title: Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2.
Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development.
Title: Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development.
SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish.
Title: SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish.
The ezh2 mRNA and Ezh2 protein were present during adulthood (70 days post-fertilization) in both wild type and ezh2(sa1199), R18STOP (stop mutation in the second exon of the ezh2 gene) mutant zebrafish. Study concludes that the ezh2(sa1199) allele does not exhibit an ezh2 loss-of-function phenotype.
Title: The ezh2(sa1199) mutant zebrafish display no distinct phenotype.
Ezh2 contributes to hematopoiesis by enhancing expression of hematopoietic genes such as cmyb and lck. Together, our findings demonstrate for the first time that Ezh2 acts in both circadian regulation and hematopoiesis independent of silencing PRC2.
Title: Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish.
Ezh2 is essential to sustain tissue integrity and to set up proper maternal mRNA contribution.
Title: Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.
ezh2-deficient mutants fail to properly regenerate their spinal cord after caudal fin transection suggesting that Ezh2 and H3K27me3 methylation might also be involved in the process of regeneration in zebrafish.
Title: The histone lysine methyltransferase Ezh2 is required for maintenance of the intestine integrity and for caudal fin regeneration in zebrafish.

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General gene information

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Markers

fa95c09.y1 (e-PCR)
- UniSTS:189701

fc12c06.x1 (e-PCR)
- UniSTS:192559

fc12c06.x1 (e-PCR)
- UniSTS:192560

fj43a08.x1 (e-PCR)
- UniSTS:199343

fk38b05.y1 (e-PCR)
- UniSTS:200943

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EZH2

Names: enhancer of zeste homolog 2; eyes absent homolog 2

NP_001070747.1

EC 2.1.1.356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077279.1 → NP_001070747.1 histone-lysine N-methyltransferase EZH2

See identical proteins and their annotated locations for NP_001070747.1

Status: PROVISIONAL

Source sequence(s)

BC124588

UniProtKB/Swiss-Prot

Q08BS4

Related

ENSDARP00000023693.8, ENSDART00000024722.10

Conserved Domains (2) summary

smart00317
Location:626 → 747

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:39 → 67

EZH2_WD-Binding; WD repeat binding protein EZH2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

17345535..17364454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001040292.1: Suppressed sequence

Description

NM_001040292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.