wdr75 WD repeat domain 75 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr75provided by ZNC
Official Full Name: WD repeat domain 75provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-5
See related: Ensembl:ENSDARG00000040730 AllianceGenome:ZFIN:ZDB-GENE-030616-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb990; flj12519; zgc:55748; wu:fb53f09; wu:fb96h05; si:dz73o4.1; SI:dZ46I22.2; si:by113d7.2; si:by68f21.1; si:by134g18.1; si:xx-113d7.2
Summary: Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to act upstream of or within rRNA processing. Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and segmental plate. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (41120158..41153882, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (41318371..41352095, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI497447 (e-PCR)
- UniSTS:206344

fb96h05 (e-PCR)
- UniSTS:189121

fb53f09.x1 (e-PCR)
- UniSTS:190686

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing protein 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200090.1 → NP_956384.1 WD repeat-containing protein 75

See identical proteins and their annotated locations for NP_956384.1

Status: PROVISIONAL

Source sequence(s)

BC045446

UniProtKB/Swiss-Prot

Q7ZVR1, Q7ZZ52, Q8AUI8, Q8AW19, Q8JFV9

Related

ENSDARP00000059666.5, ENSDART00000059667.7

Conserved Domains (3) summary

COG2319
Location:23 → 318

WD40; WD40 repeat [General function prediction only]

sd00039
Location:61 → 99

7WD40; WD40 repeat [structural motif]

cl02567
Location:25 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...