coro1a coronin, actin binding protein, 1A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: coro1aprovided by ZNC
Official Full Name: coronin, actin binding protein, 1Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9512
See related: Ensembl:ENSDARG00000054610 AllianceGenome:ZFIN:ZDB-GENE-030131-9512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj83g12; zgc:63766; wu:fj83g12
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within brain development; central nervous system projection neuron axonogenesis; and eye development. Predicted to be located in cytoplasm. Is expressed in several structures, including ball; endothelial cell; hematopoietic cell; hematopoietic system; and thymus. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to human CORO1A (coronin 1A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (30926356..30941289, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (30795514..30810447, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils
Title: Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils.

Submit: New GeneRIF Correction

General gene information

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Markers

fj83g12.x1 (e-PCR)
- UniSTS:200061

fb14b10.x1 (e-PCR)
- UniSTS:190125

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coronin-1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201114.1 → NP_957408.1 coronin-1A

See identical proteins and their annotated locations for NP_957408.1

Status: PROVISIONAL

Source sequence(s)

BC055237

UniProtKB/TrEMBL

A0A2R8Q5C9, F6NPY9, Q7SX58

Related

ENSDARP00000071301.4, ENSDART00000076830.5

Conserved Domains (4) summary

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:344 → 386

WD40_4; Type of WD40 repeat

sd00039
Location:39 → 79

7WD40; WD40 repeat [structural motif]

cl02567
Location:76 → 301

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...