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    rxrga retinoid x receptor, gamma a [ Danio rerio (zebrafish) ]

    Gene ID: 30464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rxrgaprovided by ZNC
    Official Full Name
    retinoid x receptor, gamma aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-36
    See related
    Ensembl:ENSDARG00000005593 AllianceGenome:ZFIN:ZDB-GENE-980526-36
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RXR; rxra; rxrg; NR2B1
    Summary
    Enables nuclear receptor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within intracellular receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including mesoderm; neural rod; pharyngeal arch; retina; and tail bud. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    all
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    Genomic context

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    See rxrga in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20725684..20776841)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21067712..21118926)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 12 Neighboring gene uncharacterized LOC110438025 Neighboring gene proteoglycan 4a Neighboring gene translocated promoter region a, nuclear basket protein Neighboring gene odr-4 GPCR localization factor homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt. Walker SE, et al. Neural Regen Res, 2018 Jun. PMID 29926831, Free PMC Article
    2. Estrogenic effects of nonylphenol and octylphenol isomers in vitro by recombinant yeast assay (RYA) and in vivo with early life stages of zebrafish. Puy-Azurmendi E, et al. Sci Total Environ, 2014 Jan 1. PMID 23892017
    3. The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Gauchat D, et al. Dev Biol, 2004 Nov 1. PMID 15464576
    4. Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development. Hale LA, et al. Gene Expr Patterns, 2006 Jun. PMID 16455309
    5. Retinoid requirements in the reproduction of zebrafish. Alsop D, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18158153

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
      Title: Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
    2. The RA receptors RXR gamma and RAR alpha-b are expressed in patterns consistent with mediating the effects of RA on photoreceptors.
      Title: Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinoic acid receptor RXR-gamma-A
    Names
    NR2B3
    nr2b3a
    nuclear receptor subfamily 2 group B member 3-A
    retinoic acid receptor RXR-alpha
    retinoid X receptor alpha
    retinoid X receptor gamma-A
    retinoid receptor-alpha
    retinoid x receptor, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131217.4 → NP_571292.3  retinoic acid receptor RXR-gamma-A

      Status: VALIDATED

      Source sequence(s)
      BC059576, CABZ01020455, CABZ01063427, CABZ01063428, CU855759, EH435141, FO681336
      UniProtKB/Swiss-Prot
      Q6PBU9, Q90416
      UniProtKB/TrEMBL
      A0A8N1TSS1
      Related
      ENSDART00000021168.9
      Conserved Domains (3) summary
      cd06943
      Location:211 → 419
      NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
      cd06956
      Location:115 → 191
      NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
      pfam11825
      Location:40 → 111
      Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      20725684..20776841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90416.2 GenPept UniProtKB/Swiss-Prot:Q90416

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.